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Gait Deviations in Children With Osteogenesis Imperfecta Type I

Christina R Garman1, Adam Graf2, Joseph Krzak2,3

  • 1Orthopaedic and Rehabilitation Engineering Center, Marquette University, Milwaukee, WI.

Journal of Pediatric Orthopedics
|August 9, 2019
PubMed

Insights

Individuals with Osteogenesis Imperfecta (OI) exhibit distinct gait deviations, including slower walking speed and altered joint mechanics. Understanding these differences in gait is crucial for developing targeted interventions to improve mobility and quality of life in OI patients.

Area of Science:

  • Orthopaedics
  • Biomechanics
  • Human Movement Science

Background:

  • Osteogenesis Imperfecta (OI) is a genetic disorder affecting connective tissue, frequently leading to orthopaedic issues that impair gait and mobility.
  • Impaired mobility in OI significantly impacts participation and overall quality of life, making gait analysis critical for this population.

Purpose of the Study:

  • To identify and characterize common gait deviations in individuals with type I OI.
  • To explore the underlying causes of these gait deviations with the aim of enhancing functional outcomes.

Main Methods:

  • Gait analysis was conducted on 44 individuals with type I OI and 30 typically developing controls.
  • Kinematic and kinetic data were collected using the Vicon Plug-in-Gait Model, alongside musculoskeletal modeling to assess muscle tendon lengths (MTL).
  • The Gait Deviation Index (GDI) was calculated to quantify deviations from normative gait parameters.

Main Results:

  • The OI group demonstrated reduced walking speed, single support time, stride length, and step length, with increased double support time.
  • Individuals with OI had lower GDI scores and increased external hip rotation angles compared to controls.
  • Reduced peak moments and power generation were observed in hip flexors, knee extensors, and ankle plantarflexors in the OI group, with no significant MTL discrepancies.

Conclusions:

  • This study provides a detailed profile of gait characteristics in individuals with type I OI.
  • The findings offer valuable insights for clinicians to implement more targeted interventions for improving gait function in this population.
Abstract

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