Related Experiment Video

Updated: Jan 21, 2026

Intravitreal Injections in the Ovine Eye
03:37

Intravitreal Injections in the Ovine Eye

Published on: July 5, 2022

4.0K

[Antibiotic resistance in patients after serial intravitreal injections]

G V Voronin1, M V Budzinskaya1, M G Strakhovskaya2

  • 1Research Institute of Eye Diseases, 11A Rossolimo St., Moscow, Russian Federation, 119021.

Vestnik Oftalmologii
|August 9, 2019
PubMed

Insights

Topical antibiotic use before eye injections lacks proven benefit for preventing post-injection endophthalmitis (PIE). Routine antibiotic use promotes resistant bacterial strains, potentially increasing eye infection risk.

Area of Science:

  • Ophthalmology
  • Microbiology
  • Infectious Diseases

Background:

  • Topical antibiotic prophylaxis is commonly used before intravitreal injections.
  • Evidence supporting its efficacy in preventing post-injection endophthalmitis (PIE) is limited.
  • This practice may contribute to the development of antibiotic resistance.

Purpose of the Study:

  • To evaluate the necessity and potential risks of routine topical antibiotic use.
  • To analyze the impact of frequent antibiotic administration on ocular surface microbiota.
  • To highlight the emergence of resistant bacterial strains due to selective pressure.

Main Methods:

  • Review of current clinical practices and available scientific literature.
  • Analysis of the effects of antibiotic exposure on bacterial flora composition.
  • Assessment of the link between antibiotic resistance and ocular infection severity.

Main Results:

  • Convincing data on the effectiveness of topical antibiotics in PIE prevention is lacking.
  • Frequent antibiotic use alters conjunctival flora composition.
  • Selective survival of resistant and virulent bacterial strains is observed.

Conclusions:

  • The routine use of topical antibiotics before intravitreal injections may be unwarranted.
  • This practice can lead to the proliferation of resistant pathogens.
  • Potential risks include increased virulence and severe intraocular damage.
Keywords:
antibioticsendophthalmitisintravitreal injectionsresistanceresistant strains

More Related Videos

Intravitreous Injection for Establishing Ocular Diseases Model05:37

Intravitreous Injection for Establishing Ocular Diseases Model

Published on: October 1, 2007

37.8K
Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes08:58

Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes

Published on: March 3, 2023

7.7K

Related Concept Videos

Development of Antibiotic Resistance01:30

Development of Antibiotic Resistance

Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
1.4K
Antibiotic Selection00:57

Antibiotic Selection

Overview
59.5K
Serial Position Effect01:03

Serial Position Effect

The serial position effect is a cognitive phenomenon where individuals are more likely to recall the first and last items in a list compared to those in the middle. This effect is divided into the primacy effect and the recency effect. The primacy effect is observed when the initial items in a list are remembered better. This occurs because these items are rehearsed more frequently or receive more elaborative processing, allowing them to be encoded into long-term memory more effectively. For...
528
Resistivity01:22

Resistivity

When a voltage is applied to a conductor, an electrical field is generated, and charges in the conductor feel the force due to the electrical field. The current density that results depends on the electrical field and the properties of the material. In some materials, including metals at a given temperature, the current density is approximately proportional to the electrical field. In these cases, the current density can be modeled as:
4.4K
Resistance01:19

Resistance

When a current moves through any conductor, the conductor causes some level of difficulty for the current to flow. The measure of that difficulty is known as the resistance of the material and is represented by R. Every material has its own resistance. In the case of conductors, heat is emitted whenever a current passes through them. Resistance depends on the resistivity of the material. Resistivity is a characteristic of the material used to fabricate electrical components, whereas the...
5.7K
Resistance and Conductance01:25

Resistance and Conductance

A conductor's DC resistance at a given temperature is influenced by its resistivity, length, and cross-sectional area. Resistivity is an inherent property of the conductor material, with annealed copper serving as the international standard for measurement. For instance, the resistivity of hard-drawn aluminum at 20 degrees Celsius is 61% of the standard conductivity of annealed copper.
Various factors impact the resistance of a conductor. Spiraling in stranded conductors increases their...
494