Related Experiment Video
Updated: Jan 21, 2026

Author Spotlight: Improving Radiation Therapy Access with Radiation Planning Assistant
Published on: October 6, 2023
Clinical evaluation of chairside Computer Assisted Design/Computer Assisted Machining nano-ceramic restorations:
Dennis J Fasbinder1, Gisele F Neiva1, Donald Heys1
1Department of Cariology, Restorative Sciences, and Endodontics, School of Dentistry, University of Michigan, Ann Arbor, Michigan.
Nano-ceramic onlays demonstrate comparable 5-year clinical performance to leucite-reinforced ceramic onlays, with a lower fracture rate. This study confirms their durability for chairside CAD/CAM restorations.
Area of Science:
- Dental Materials Science
- Biomaterials Engineering
- Restorative Dentistry
Background:
- Chairside Computer Assisted Design/Computer Assisted Machining (CAD/CAM) restorations utilize various ceramic materials.
- A new category of resilient nano-ceramic materials offers potential advantages in durability and handling.
- Long-term clinical data on these novel nano-ceramic materials is limited.
Purpose of the Study:
- To evaluate the 5-year clinical performance of nano-ceramic (Lava Ultimate/3M) onlays fabricated chairside using CAD/CAM.
- To compare the clinical outcomes of nano-ceramic onlays with leucite-reinforced ceramic onlays.
- To assess the impact of self-etch versus total etch cementation techniques on onlay retention and performance.
Main Methods:
- A 5-year longitudinal, randomized clinical trial involving 120 patients.
- Sixty chairside CAD/CAM onlays were fabricated from leucite-reinforced ceramic and 60 from nano-ceramic material.
- Onlays were cemented using either a self-etch or a total etch adhesive resin cement, with equal distribution between groups.
Main Results:
- Postoperative sensitivity was transient, resolving within 4 weeks for all onlays.
- Four leucite-reinforced ceramic onlays and one nano-ceramic onlay fractured over the 5-year period.
- No debonding was reported, regardless of the cementation technique (self-etch or total etch).
Conclusions:
- Both self-etch and total etch cementation techniques yield similar clinical outcomes for CAD/CAM onlays, with no adhesive failures.
- Nano-ceramic onlays exhibited a lower incidence of fracture compared to leucite-reinforced ceramic onlays.
- Nano-ceramic onlays demonstrated comparable clinical performance to glass-ceramic onlays over 5 years of service.
Related Concept Videos
Restorative Care
Matrix-Assisted Laser Desorption Ionization (MALDI)
Machines
A free-body diagram of the...
Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation
Machines: Problem Solving II

