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Measurements of Motor Function and Other Clinical Outcome Parameters in Ambulant Children with Duchenne Muscular Dystrophy
Published on: January 12, 2019
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Chagasic Megaesophagus-Associated Carcinoma: Clinical Pattern and Outcomes
Mariane C L Martins1, Daniela L Miyazaki1, Camila C T Gabiatti1
1State University of Campinas, Campinas, Brazil.
Journal of Global Oncology
|August 9, 2019
Summary
Chagas-induced megaesophagus patients with esophageal carcinoma (CMAC) have a poor prognosis if not detected early. Early detection and treatment are crucial for improving survival in this high-risk group.
Area of Science:
- Gastroenterology
- Oncology
- Infectious Diseases
Background:
- Chagas disease can lead to megaesophagus, increasing esophageal carcinoma risk.
- The clinical presentation and outcomes of Chagas megaesophagus-associated carcinoma (CMAC) are poorly understood.
Purpose of the Study:
- To describe the natural history and clinical patterns of esophageal carcinoma in patients with Chagas-induced megaesophagus.
- To evaluate the epidemiologic profile and oncological treatment outcomes of CMAC.
Main Methods:
- Retrospective analysis of 593 esophageal carcinoma patients.
- Identification and evaluation of 11 patients with Chagas megaesophagus-associated carcinoma (CMAC).
Main Results:
- CMAC patients showed a lower smoking rate, suggesting achalasia as a key risk factor.
- A higher rate of in situ tumors was observed in CMAC patients, with successful endoscopic resection.
- Locally advanced CMAC had a median progression-free survival of 7.8 months and overall survival of 9.1 months.
Conclusions:
- CMAC has a dismal prognosis if not detected early, necessitating a high index of suspicion.
- Further research is needed to enhance surveillance and treatment strategies for this neglected condition.
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