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Comparison of systemic conditions at diagnosis between central retinal vein occlusion and branch retinal vein

Bum-Joo Cho1, So Hyun Bae2, Sang Min Park3

  • 1Department of Ophthalmology, Hallym University College of Medicine, Hallym University Sacred Heart Hospital, Anyang, Korea.

Plos One
|August 9, 2019
PubMed

Insights

Central retinal vein occlusion (CRVO) is linked to more diabetes, kidney disease, and high homocysteine than branch retinal vein occlusion (BRVO). This suggests different underlying causes for these retinal conditions.

Area of Science:

  • Ophthalmology
  • Vascular Medicine
  • Nephrology

Background:

  • Retinal vein occlusions (RVOs) are a significant cause of vision loss.
  • Central retinal vein occlusion (CRVO) and branch retinal vein occlusion (BRVO) are distinct clinical entities.
  • Understanding systemic associations is crucial for managing RVOs.

Purpose of the Study:

  • To compare the systemic conditions at diagnosis between patients with CRVO and BRVO.
  • To identify potential differences in the underlying pathophysiology of CRVO versus BRVO.

Main Methods:

  • Retrospective analysis of 1,928 patients diagnosed with CRVO or BRVO.
  • Data collected included demographics, comorbidities, and laboratory findings.
  • Statistical comparison of systemic profiles between CRVO and BRVO groups.

Main Results:

  • CRVO patients showed higher prevalence of diabetes mellitus and chronic kidney disease.
  • Elevated serum homocysteine levels were significantly more common in the CRVO group.
  • CRVO group also had higher abnormal blood urea nitrogen and serum creatinine levels.

Conclusions:

  • CRVO is associated with a greater burden of systemic comorbidities, including diabetes and kidney disease.
  • Elevated homocysteine levels may play a role in CRVO pathophysiology.
  • Findings suggest distinct systemic associations and potentially different pathophysiological mechanisms for CRVO and BRVO.
Abstract

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