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Related Concept Videos

Bipolar Disorder01:30

Bipolar Disorder

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Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.
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Related Experiment Video

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Developing a Rat Model for Bipolar Disorder
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Lithium prophylaxis in early-onset Bipolar disorder: a descriptive study.

Sandhiya Selvarajan1, Harshini Manohar2, Saibal Das1

  • 1JIPMER, Department of Clinical Pharmacology, Dhanvantri Nagar, Puducherry, 605006, India.

Asian Journal of Psychiatry
|August 9, 2019
PubMed
Summary

This study examined early-onset Bipolar I disorder in India, finding a mean age of onset at 16.13 years. Further research is needed on the clinical profile and lithium treatment response in this population.

Keywords:
AdolescentBipolarEarly-onsetLithiumTreatment

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Area of Science:

  • Psychiatry
  • Neuroscience
  • Clinical Psychology

Background:

  • Early-onset Bipolar I disorder presents unique challenges in diagnosis and treatment.
  • Lithium is a common mood stabilizer, but its efficacy and safety in adolescent-onset bipolar disorder require specific investigation.
  • Understanding the clinical characteristics and treatment outcomes in diverse populations, such as in India, is crucial.

Purpose of the Study:

  • To investigate the clinical profile of early-onset Bipolar I disorder in an Indian cohort.
  • To examine the age of onset and initiation of lithium treatment in these patients.
  • To lay the groundwork for future studies on treatment response in this demographic.

Main Methods:

  • Screening of 575 subjects with Bipolar Disorder to identify those meeting DSM-5 criteria for early-onset Bipolar I disorder.
  • Enrollment of 52 patients on lithium prophylaxis into prospective and retrospective study arms.
  • Analysis of demographic and clinical data, including age at onset and age at lithium initiation.

Main Results:

  • The study included 52 patients with early-onset Bipolar I disorder (onset before 18 years).
  • The mean age at disorder onset was 16.13 years.
  • Approximately 31% of patients were initiated on lithium after their first episode, with a mean age of 19.73 years for initiation.

Conclusions:

  • Early-onset Bipolar I disorder in the Indian context is characterized by onset in mid-adolescence.
  • Lithium initiation often occurs several years after the initial episode.
  • Further research is essential to understand the clinical profile and optimize lithium treatment response for early-onset Bipolar I disorder in India.