Down-regulation of BRMS1 mRNA Expression in Breast Cancer is not Related to the Presence of Axillary Node Metastasis
F Gomez-Esquer1, D Agudo1, F Martinez-Arribas2
1Universidad Rey Juan Carlos, Facultad de Ciencias de la Salud, Madrid.
Background:
BRMS1, recently identified in MDA-MB-435 breast cancer cells, seems to act as a potent antimetastatic gene in experimental tumor models.
Materials And Methods:
To verify if BRMS1 exerts its action in a similar way in clinical tumors, BRMS1-mRNA expression was investigated in a series of 107 human breast carcinomas and correlated with the presence or not of axillary node metastases. Additionally, BRMS1 expression was correlated with all available clinical (histologic variety, histologic and nuclear grade) and biological parameters (ploidy, expression of Ki67, hormone receptors, c-erb-B2 and p53), as well as with the expression of hMAM- and Nup88-mRNA, previously shown by us to correlate with very low and very high aggressiveness of breast cancer, respectively.
Results:
Down-regulation of BRMS1 expression in the tumors did not correlate with the presence of axillary node metastases. Furthermore, BRMS1 expression did not correlate with any other of the studied clinical or biological tumor parameters.
Conclusion:
In clinical breast cancers, down-regulation of BRMS1 expression seems not to mimic the very clear-cut antimetatstatic properties displayed in experimental tumor models.
Insights
BRMS1 gene expression in human breast cancer did not correlate with metastasis or other clinical factors. Its potent antimetastatic effect seen in lab models does not appear to translate to human tumors.
Area of Science:
- Oncology
- Molecular Biology
- Cancer Research
Background:
- BRMS1 is a gene identified in breast cancer cells.
- BRMS1 shows potent antimetastatic properties in experimental tumor models.
Purpose of the Study:
- To investigate if BRMS1 gene expression in human breast carcinomas correlates with metastatic potential.
- To examine the relationship between BRMS1 expression and clinical/biological parameters in breast cancer.
Main Methods:
- Analyzed BRMS1-mRNA expression in 107 human breast carcinomas.
- Correlated BRMS1 expression with axillary node metastasis, clinical factors, and other gene expressions (hMAM, Nup88).
Main Results:
- Down-regulation of BRMS1 expression did not correlate with the presence of axillary node metastases.
- BRMS1 expression showed no correlation with clinical or biological tumor parameters studied.
Conclusions:
- BRMS1's antimetastatic properties observed in experimental models do not appear to be replicated in clinical human breast cancers.
- The role of BRMS1 in human breast cancer progression needs further investigation.
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