Related Experiment Video
Updated: Jan 21, 2026

Comparison of Three Different Methods for Determining Cell Proliferation in Breast Cancer Cell Lines
Published on: September 3, 2016
A Comparison of KGF Receptor Expression in Various Types of Human Cancer
Xiao-Ping Zang1, Megan R Lerner2,3, Steven J Bahr1
1Department of Pharmaceutical Sciences, University of Oklahoma Health Sciences Center.
Background:
Keratinocyte growth factor (KGF) has been observed to produce a rapid increase in the motility of breast cancer cells. KGF/KGFR (KGF receptor) signaling has also been demonstrated in the progression of many types of human cancer. The objective of the present study was to compare KGFR expression in various types of cancer.
Materials And Methods:
A cancer profiling array containing cDNA from 154 tumor and paired normal samples representing 19 types of human cancer was employed.
Results:
The results of the present study indicate that KGFR expression is enhanced in many types of human carcinomas at an early stage of cancer development, suggesting that KGFR overexpression may be an early signal in the progression of these cancers. However, the stage of cancer progression and relative level of expression varied considerably among the various types of cancer.
Conclusion:
These findings suggest that tumor KGFR levels may serve as a prognostic biomarker for cancer staging and/or treatment.
Related Concept Videos
Types of Receptors: Internal Receptors
Similar to membrane-bound receptors, the binding of a ligand to the intracellular receptor of causes a conformational change in the...
Types of Receptors: Cell Surface Receptors
The Sense of Self: Reflected Self-Appraisal and Social Comparison
Internal Receptors
Types of Hormones
Chromatin Position Affects Gene Expression
Topologically Associated Domains (TADs)
The 3-dimensional positioning of chromatin in the nucleus influences the...

