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Metastasis Promoter S100A4 is a Potential Molecular Therapeutic Target.

G V Sherbet1,2

  • 1School of Electrical, Electronic and Computer Engineering, University of Newcastle upon Tyne, U.K. gajanan.sherbet@ncl.ac.uk.

Cancer Genomics & Proteomics
|August 10, 2019
PubMed
Summary

S100A4 protein is a key player in cancer growth and spread. Targeting S100A4 pathways offers a promising strategy to inhibit tumor development, invasion, and metastasis, validating it as a crucial therapeutic target.

Keywords:
AngiogenesisS100A4VEGF signallingcancer invasioncell cycle regulationcytoskeletal dynamicsgrowth factor signallinglymphangiogenesismetastasisreviewtherapeutic target

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Oncology

Background:

  • S100A4 is a calcium-binding protein implicated in tumor progression.
  • Its involvement in diverse signaling pathways highlights its significance in cancer.

Purpose of the Study:

  • To explore the signaling pathways utilized by S100A4.
  • To identify effective therapeutic targets for inhibiting cancer growth, invasion, and metastasis.

Main Methods:

  • Review and analysis of existing literature on S100A4 signaling pathways.
  • Identification of potential drug targets within these pathways.

Main Results:

  • S100A4 influences cell cycle regulators, growth factor receptors, and angiogenesis.
  • Targeting S100A4 can down-regulate phenotypic activities driving cancer progression.

Conclusions:

  • S100A4 is a validated therapeutic target for controlling cancer growth, invasion, and metastasis.
  • Inhibiting or deregulating S100A4 function presents a viable strategy for cancer therapy.