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Gingers and Their Purified Components as Cancer Chemopreventative Agents

John F Lechner1, Gary D Stoner2

  • 1Retired from Department of Medicine, Division of Medical Oncology, Ohio State University, Columbus 43210, OH, USA. johnf.lechner@gmail.com.

Molecules (Basel, Switzerland)
|August 10, 2019
PubMed

Insights

Ginger compounds can prevent cancer by normalizing gene activity disrupted by oxidative stress and inflammation. This review explores how ginger

Area of Science:

  • Nutritional Science
  • Oncology
  • Molecular Biology

Background:

  • Chemoprevention involves using nutraceuticals or bioactive compounds to counteract cancer development.
  • Carcinogenesis is a multi-step process (initiation, promotion, progression) driven by oxidative stress and inflammation.
  • These processes lead to aberrant gene expression and mutations, transforming normal cells into neoplastic cells.

Purpose of the Study:

  • To review the chemoprevention activities of ginger.
  • To discuss how ginger compounds normalize gene expression during carcinogenesis.

Main Methods:

  • Literature review of studies on ginger's chemopreventive effects.
  • Analysis of mechanisms by which ginger affects gene expression related to cancer.

Main Results:

  • Ginger and its bioactive components can antagonize carcinogenesis.
  • Ginger normalizes aberrant gene activities crucial in cancer development.
  • Specific ginger compounds influence various gene expressions involved in cancer.

Conclusions:

  • Ginger exhibits significant chemopreventive potential.
  • Ginger's ability to modulate gene expression is key to its anti-cancer effects.
  • Further research into ginger as a chemopreventive agent is warranted.
Keywords:
apoptosiscancer chemopreventiongingerolsparadolsshogaolszerumbonezingerone

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