Two New Flavonoids from the Nuts of Areca catechu

Two new flavonoids, calquiquelignan M (1), calquiquelignan N (2), along with nine known compounds (3-11), were isolated from the nuts of Areca catechu (Palmae). The new structures, including absolute configurations, were established by a combination of spectroscopic data and electronic circular dichroism (ECD) calculation. The known compounds were identified by comparing their spectroscopic data with reported in the literature. The flavonoids compounds (1-8) were evaluated for their cytotoxicity activities against three human cancer cell lines. Compounds 1 and 2 exhibited a moderate cytotoxic activity against HepG2 cell lines with IC₅₀ values of 49.8 and 53.6 μM, respectively.