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MicroRNA-361: A Multifaceted Player Regulating Tumor Aggressiveness and Tumor Microenvironment Formation

Daozhi Xu1, Peixin Dong2, Ying Xiong3

  • 1Department of Obstetrics and Gynecology, Hokkaido University School of Medicine, Hokkaido University, Sapporo 060-8638, Japan.

Cancers
|August 10, 2019
PubMed

Insights

MicroRNA-361-5p (miR-361) is often lost in cancers, acting as a tumor suppressor. Its restoration may offer new diagnostic and therapeutic strategies for cancer treatment.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • MicroRNA-361-5p (miR-361) expression is frequently downregulated or absent in various human cancers.
  • This downregulation is linked to increased tumor aggressiveness and poor patient outcomes.

Purpose of the Study:

  • To review the expression patterns of miR-361 in human tumors.
  • To elucidate the mechanisms behind miR-361 dysregulation.
  • To discuss the role of miR-361 as a tumor suppressor in modulating cancer cell properties and the tumor microenvironment.

Main Methods:

  • Literature review of studies on miR-361 expression and function in cancer.
  • Analysis of mechanisms causing miR-361 dysregulation.
  • Discussion of miR-361's impact on tumor growth, metastasis, drug resistance, and angiogenesis.

Main Results:

  • miR-361 acts as a tumor suppressor by inhibiting target genes involved in tumor progression.
  • Dysregulation of miR-361 contributes to cancer development and progression.
  • miR-361 influences epithelial-to-mesenchymal transition (EMT), glycolysis, and inflammation in the tumor microenvironment.

Conclusions:

  • miR-361 exhibits significant tumor-suppressive functions across various cancers.
  • Restoring miR-361 levels holds potential for cancer therapy.
  • miR-361 may serve as a valuable diagnostic and prognostic biomarker for cancer.
Keywords:
EMTangiogenesiscancer diagnosiscancer treatmentmicroRNA-361tumor microenvironment

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