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Multidisciplinary Approach to Obesity Management: A Case Report
Published on: May 30, 2025
Effects of birth weight on body composition and overweight/obesity at early school age
Jing Zhou1, Lingxia Zeng2, Duolao Wang3
1Department of Pediatrics, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, PR China.
Insights
Higher birth weight is linked to increased risk of overweight and obesity in young boys. This association highlights the need to consider sex differences in childhood obesity prevention strategies.
Area of Science:
- Pediatrics
- Public Health
- Epidemiology
Background:
- Childhood obesity prevalence is rising globally.
- Birth weight is a potential early indicator of later health outcomes.
- Understanding factors influencing childhood body composition is crucial for public health.
Purpose of the Study:
- To investigate the association between birth weight and body composition in early school-aged children.
- To determine if birth weight predicts overweight or obesity at ages 7-10.
- To explore potential sex differences in this relationship.
Main Methods:
- Analysis of data from 1669 children (7-10 years) from a micronutrient supplementation trial.
- Prospective collection of body composition, demographic, and behavioral data.
- Statistical modeling (generalized estimating equations) to assess trends across birth weight quintiles.
Main Results:
- Higher birth weight quintiles showed significant upward trends in fat mass index, fat-free mass index, and body fat percentage for both boys and girls.
- Boys with higher birth weights (third to top quintiles) had increased risk ratios for overweight/obesity compared to the reference group.
- Prevalence of overweight/obesity was 7.4% in boys and 5.0% in girls.
Conclusions:
- Elevated birth weight is associated with a higher risk of overweight/obesity in school-aged boys.
- The findings suggest sex-specific considerations are necessary for interventions targeting childhood obesity.
- Early life factors like birth weight play a role in long-term body composition and weight status.
Objectives:
The prevalence of childhood obesity has increased substantially. We aimed to characterize the effect of birth weight on body composition and overweight/obesity at early school age.
Study Design:
A total of 1669 children with available birth records from a double-blind cluster-randomized controlled trial exploring micronutrient supplementation during pregnancy were included. Data regarding school-aged body composition, social-demographic factors and health behaviours were prospectively collected.
Result:
s: The study population consisted of 1004 boys and 665 girls aged between 7 and 10 years. The prevalence of overweight/obesity (>85th age-sex-specific percentiles) was 7.4% for boys and 5.0% for girls. Generalized estimating equation models were used to account for the cluster nature of the data. A significant upward trend across quintiles of birth weight was observed for fat mass index (boys: P for trend 0.002; girls: P for trend <0.001), fat-free mass index (boys: P for trend <0.001; girls: P for trend <0.001), and percentage of body fat (boys: P for trend 0.003; girls: P for trend <0.001). A birth weight in the higher three quintiles could increase the risk ratios [RRs (95% CI) third quintile: 2.88, (1.13, 7.32); fourth quintile: 2.40, (0.87, 6.66); top quintile: 2.31, (0.92, 5.80)] of overweight/obesity at early school age compared with the RRs of the reference group (the second quintile of birth weight) among boys.
Conclusions:
Higher birth weight could increase the risk of being overweight/obese among 7- to 10-year-old boys in rural western China. Sex differences in this association need to be considered when planning interventions.
Research Registration:
This trial was registered at www.isrctn.com with the identifier ISRCTN08850194.
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