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Olanexidine gluconate versus povidone-iodine for preventing surgical-site infection in orthopaedic surgery: A

Mitsuru Asukai1, Tsuyoshi Ohishi1, Tomotada Fujita1

  • 1Department of Orthopaedic Surgery, Enshu Hospital, 1-1-1 Chuo, Naka-ku, Hamamatsu, Shizuoka 430-0929, Japan.

Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association
|August 10, 2019
PubMed
Abstract

Insights

Olanexidine gluconate (OLG) shows similar efficacy to povidone-iodine (PVP-I) in preventing surgical-site infections in orthopaedic surgery. However, OLG was associated with a higher rate of adverse skin reactions.

Area of Science:

  • Infectious Disease
  • Surgical Safety
  • Dermatology

Background:

  • Olanexidine gluconate (OLG) is a novel antiseptic with broad-spectrum antibacterial activity.
  • It is effective against resistant bacteria like MRSA and VRE.
  • OLG's potential in orthopaedic surgery required evaluation.

Purpose of the Study:

  • To compare the efficacy of OLG versus povidone-iodine (PVP-I) in preventing surgical-site infections (SSI).
  • To assess the safety profile, specifically adverse skin reactions, of OLG in orthopaedic patients.

Main Methods:

  • Retrospective study of 1103 patients undergoing clean orthopaedic surgery.
  • Patients were divided into OLG group (n=556) and PVP-I group (n=547).
  • Outcomes measured: SSI rates within 30 days and adverse skin reactions.

Main Results:

  • No significant difference in overall SSI rates between OLG (1.80%) and PVP-I (2.38%) groups (p=0.50).
  • Superficial and deep incisional infection rates were also similar between groups.
  • Adverse skin reactions were significantly higher in the OLG group (2.16%) compared to the PVP-I group (0.73%) (p=0.047).

Conclusions:

  • OLG demonstrates comparable efficacy to PVP-I in preventing SSIs in clean orthopaedic procedures.
  • The increased incidence of adverse skin reactions with OLG warrants careful consideration.
  • Further investigation into managing OLG-associated skin reactions may be necessary.

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