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In vitro activity of eight antimicrobial agents against non-penicillinase-producing gonococci isolated in Munich

D Abeck1, A P Johnson, F Alexander

  • 1Division of Sexually Transmitted Diseases, MRC Clinical Research Centre, Harrow, Middlesex.

Genitourinary Medicine
|August 1, 1988
PubMed

Insights

Antibiotic resistance in Neisseria gonorrhoeae is a growing concern. However, in 1986 Munich isolates, all strains remained susceptible to newer antibiotics like ciprofloxacin and cefotaxime.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Pharmacology

Background:

  • Neisseria gonorrhoeae is a significant cause of sexually transmitted infections.
  • Emerging antibiotic resistance poses a threat to gonorrhea treatment.
  • Monitoring antimicrobial susceptibility is crucial for public health.

Purpose of the Study:

  • To assess the antibiotic susceptibility profile of Neisseria gonorrhoeae strains.
  • To evaluate resistance patterns to commonly used antibiotics.
  • To identify effective antimicrobial agents against gonorrhea.

Main Methods:

  • Isolated 119 strains of Neisseria gonorrhoeae from Munich in 1986.
  • Tested susceptibility to eight different antibiotics.
  • Determined minimum inhibitory concentrations (MICs) for spectinomycin.

Main Results:

  • Observed resistance to penicillin and tetracycline in some strains.
  • Noted high minimum inhibitory concentrations (MICs) for spectinomycin.
  • Found all strains remained sensitive to ciprofloxacin, enoxacin, fleroxacin, cefotaxime, and FCE 22250.

Conclusions:

  • While resistance to older antibiotics is present, newer agents show promise.
  • Ciprofloxacin, enoxacin, fleroxacin, cefotaxime, and FCE 22250 were effective against 1986 isolates.
  • Continued surveillance of Neisseria gonorrhoeae antibiotic susceptibility is essential.

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