Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

3.2K
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
3.2K
Diabetes: Management and Pharmacotherapy01:15

Diabetes: Management and Pharmacotherapy

873
The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
873
Psychoneuroimmunology: Diabetes and Cancer01:19

Psychoneuroimmunology: Diabetes and Cancer

462
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
462
Diabetes: Symptoms, Diagnosis, and Complications01:15

Diabetes: Symptoms, Diagnosis, and Complications

2.1K
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
2.1K
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

4.4K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
4.4K
Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

5.0K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
5.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

GLUT9b- and ABCG2-mediated collecting duct urate transport uncover a vasopressin-independent mechanism of renal water reabsorption.

The Journal of clinical investigation·2026
Same author

Canadian Society of Nephrology Commentary on the 2025 Kidney Disease Improving Global Outcomes Clinical Practice Guidelines for Autosomal Dominant Polycystic Kidney Disease.

Canadian journal of kidney health and disease·2026
Same author

Model of ocular surface ion and water transport predicts efficacy of dry eye therapeutics.

The Journal of general physiology·2026
Same author

Epithelial plasma membrane transporters as drug targets.

Physiological reviews·2026
Same author

Association of Kidney Volume With Patient-Reported Outcomes in ADPKD.

Kidney international reports·2026
Same author

Hyponatremia: Pathophysiology of different etiologies.

Best practice & research. Clinical endocrinology & metabolism·2026

Related Experiment Video

Updated: Jan 21, 2026

Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes
16:26

Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes

Published on: August 20, 2007

6.2K

Diabetes insipidus.

Mirjam Christ-Crain1,2, Daniel G Bichet3,4, Wiebke K Fenske5

  • 1Division of Endocrinology, Diabetes and Metabolism, University Hospital Basel, Basel, Switzerland. mirjam.christ-crain@unibas.ch.

Nature Reviews. Disease Primers
|August 10, 2019
PubMed
Summary
This summary is machine-generated.

Diabetes insipidus (DI) involves excessive urination. Differentiating central or nephrogenic DI from primary polydipsia requires specific tests to guide appropriate treatment.

More Related Videos

Neo-Islet Formation in Liver of Diabetic Mice by Helper-dependent Adenoviral Vector-Mediated Gene Transfer
16:59

Neo-Islet Formation in Liver of Diabetic Mice by Helper-dependent Adenoviral Vector-Mediated Gene Transfer

Published on: October 10, 2012

12.1K
A Zebrafish Model of Diabetes Mellitus and Metabolic Memory
10:03

A Zebrafish Model of Diabetes Mellitus and Metabolic Memory

Published on: February 28, 2013

26.5K

Related Experiment Videos

Last Updated: Jan 21, 2026

Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes
16:26

Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes

Published on: August 20, 2007

6.2K
Neo-Islet Formation in Liver of Diabetic Mice by Helper-dependent Adenoviral Vector-Mediated Gene Transfer
16:59

Neo-Islet Formation in Liver of Diabetic Mice by Helper-dependent Adenoviral Vector-Mediated Gene Transfer

Published on: October 10, 2012

12.1K
A Zebrafish Model of Diabetes Mellitus and Metabolic Memory
10:03

A Zebrafish Model of Diabetes Mellitus and Metabolic Memory

Published on: February 28, 2013

26.5K

Area of Science:

  • Endocrinology
  • Nephrology
  • Genetics

Background:

  • Diabetes insipidus (DI) is characterized by polyuria (excessive urine excretion) due to arginine vasopressin (AVP) deficiency (central DI) or resistance (nephrogenic DI).
  • Distinguishing DI from primary polydipsia, including dipsogenic DI, is crucial as causes and treatments differ.
  • Genetic factors for DI require evaluation, particularly in early childhood onset.

Purpose of the Study:

  • To outline the diagnostic challenges and methodologies for differentiating various forms of DI and primary polydipsia.
  • To emphasize the importance of accurate diagnosis for appropriate therapeutic strategies.

Main Methods:

  • Diagnostic differentiation involves water deprivation tests or hypertonic saline stimulation with copeptin/AVP measurement.
  • Comprehensive evaluation includes detailed medical history, physical examination, and imaging studies.
  • Genetic testing is considered for suspected inherited forms of DI.

Main Results:

  • Accurate diagnosis relies on a combination of physiological testing, biochemical markers, and clinical assessment.
  • Distinguishing DI subtypes and primary polydipsia is essential for effective management.

Conclusions:

  • Accurate diagnosis of central DI, nephrogenic DI, and primary polydipsia is achievable through careful clinical evaluation and specific diagnostic tests.
  • Tailored treatment based on the underlying etiology is critical for managing patients with DI and related disorders.