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Aspirin use is associated with reduced risk for recurrence of pyogenic liver abscess: a propensity score analysis

Jia-Sin Liu1, Chen-Hsiang Lee2,3, Seng-Kee Chuah4,5

  • 1Department of Public Health, College of Health Science, Kaohsiung Medical University, Kaohsiung, Taiwan.

Scientific Reports
|August 10, 2019
PubMed

Insights

Daily aspirin use may significantly reduce the risk of pyogenic liver abscess (PLA) recurrence in patients with Klebsiella pneumoniae PLA. This finding suggests a potential preventative role for aspirin in managing recurrent PLA cases.

Area of Science:

  • Infectious Diseases
  • Pharmacology
  • Hepatology

Background:

  • Pyogenic liver abscess (PLA), particularly Klebsiella pneumoniae PLA (KP-PLA), can recur.
  • Aspirin exhibits antibacterial properties that may influence KP-PLA recurrence.

Purpose of the Study:

  • To investigate the association between aspirin use and the recurrence of PLA.
  • To evaluate aspirin's effect on bacterial killing by leukocytes.

Main Methods:

  • A population-based cohort study identified 5,912 PLA patients in Taiwan (1999-2013).
  • Multivariate Cox proportional hazards regression analyzed aspirin use and PLA recurrence.
  • Ex-vivo bactericidal assays assessed aspirin's impact on leukocyte-mediated bacterial killing.

Main Results:

  • The PLA recurrence rate was 42.5 per 1,000 person-years for aspirin users versus 74.6 for non-users.
  • Aspirin use was associated with a 50% reduced hazard ratio (HR=0.50) for PLA recurrence.
  • Aspirin significantly enhanced bacterial killing by leukocytes in ex-vivo studies.

Conclusions:

  • Aspirin use is associated with a reduced risk of PLA recurrence in patients without pre-existing hepatobiliary diseases or malignancy.
  • Aspirin may enhance the host's immune response against K. pneumoniae, contributing to reduced recurrence.

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