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Pre-clinical Evaluation of Tyrosine Kinase Inhibitors for Treatment of Acute Leukemia
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A monoclonal antibody that recognizes a common antigen in myeloid and human T-cell leukemia virus type I-carrying

T Takeuchi1, I Kubonishi, K Takahashi

  • 1Department of Medicine, Kochi Medical School, Nankoku.

Japanese Journal of Cancer Research : Gann
|July 1, 1988
PubMed

A novel monoclonal antibody, designated D-213, was generated to human myeloid cell line PL-21. D-213 defined a 47-kD antigen which was specifically expressed in normal and leukemic cells of the myeloid lineage and in T-cell lines carrying human T-cell leukemia virus type I. This antibody was also reactive with adult T-cell leukemia/lymphoma (ATLL) cells in formalin-fixed, paraffin-embedded tissues. D-213 would be useful for making an immunohistochemical diagnosis of ATLL in cases where serological or virological information is not available.

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