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Updated: Jan 21, 2026

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale
Published on: August 25, 2014
Evaluating the effects of a neonatal hypoglycemia bundle on NICU admission and exclusive breastfeeding
Adharsh P Ponnapakkam1, Christina N Stine2, Kaashif A Ahmad3,4
1Brooke Army Medical Center, Fort Sam Houston, TX, USA. adharsh.p.ponnapakkam.mil@mail.mil.
Insights
Combining early feeding, skin-to-skin contact, and dextrose gel did not decrease neonatal intensive care unit (NICU) admissions for asymptomatic hypoglycemia or increase exclusive breastfeeding rates. Cesarean delivery was linked to lower compliance and breastfeeding success.
Area of Science:
- Neonatal care
- Pediatrics
- Public health interventions
Background:
- Neonatal hypoglycemia is a common concern, potentially leading to NICU admission.
- Early feeding, skin-to-skin contact, and dextrose gel are known to individually support breastfeeding and manage neonatal hypoglycemia.
- Combining these interventions aims to improve outcomes for asymptomatic hypoglycemia and breastfeeding.
Purpose of the Study:
- To evaluate the effectiveness of a bundled intervention for neonatal hypoglycemia.
- To assess the impact on NICU admissions for asymptomatic hypoglycemia.
- To determine the effect on exclusive breastfeeding rates at discharge.
Main Methods:
- Implementation of a bundle including early feeding (within 1 hour), skin-to-skin contact (1 hour within 2 hours), and buccal 40% dextrose gel for infants with hypoglycemia.
- Utilized the IHI Model for Improvement framework.
- Monitored NICU admissions for asymptomatic hypoglycemia and exclusive breastfeeding rates.
Main Results:
- High compliance (94%) with dextrose gel administration was achieved.
- No significant changes were observed in exclusive breastfeeding rates at discharge.
- No reduction in NICU admissions for asymptomatic hypoglycemia was detected.
- Cesarean delivery emerged as a risk factor for lower compliance and breastfeeding failure.
Conclusions:
- The bundled intervention, despite high adherence to dextrose gel use, did not reduce NICU admissions for asymptomatic hypoglycemia.
- Exclusive breastfeeding rates at discharge remained unchanged post-intervention.
- Cesarean delivery is an independent risk factor associated with challenges in implementing the bundle and achieving exclusive breastfeeding.
Objective:
Early feeding, skin-to-skin contact, and dextrose gel have been independently shown to promote breastfeeding and decrease NICU admission for neonatal hypoglycemia. We combined these interventions to decrease NICU admissions for asymptomatic hypoglycemia and increase exclusive breastfeeding rates.
Project Design:
The IHI Model for Improvement was used to design a bundle including feeding within 1 h of birth, 1 h of uninterrupted skin-to-skin within 2 h of birth, and administration of buccal 40% dextrose gel for hypoglycemic infants.
Results:
Utilization of dextrose gel was 94% following implementation. There were no trends in exclusive breastfeeding at discharge or NICU admissions for asymptomatic hypoglycemia. Post hoc multivariate analysis identified cesarean delivery as an independent risk factor for compliance failure and failure of exclusive breastfeeding but not for NICU admission.
Conclusions:
Despite high compliance with dextrose gel utilization, there was no change in exclusive breastfeeding at discharge or NICU admission rates for asymptomatic hypoglycemia.
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