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Updated: Jan 21, 2026

Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy
Published on: August 5, 2014
Altered Domain Functional Network Connectivity Strength and Randomness in Schizophrenia.
Victor M Vergara1,2,3, Eswar Damaraju1, Jessica A Turner3,4
1Tri-institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State University, Georgia Institute of Technology, Emory University, Atlanta, GA, United States.
Schizophrenia patients exhibit altered brain network connectivity. This study reveals abnormal functional connectivity strength and randomness across brain domains, suggesting significant rewiring in schizophrenia.
Area of Science:
- Neuroscience
- Psychiatry
- Computational Biology
Background:
- Functional connectivity analysis is crucial for understanding brain alterations in schizophrenia.
- Previous research identified abnormal resting-state functional connectivity at the brain network level.
Purpose of the Study:
- To investigate functional connectivity effects at whole brain and domain levels in schizophrenia.
- To assess functional connectivity strength and randomness within integrated brain domains.
Main Methods:
- Analysis of functional connectivity strength (average connectivity) and randomness (unpredictability) across brain domains.
- Comparison of these measures between individuals with schizophrenia and healthy volunteers.
Main Results:
- Schizophrenia patients showed aberrant domain connectivity strength between subcortical, cerebellar, and sensorial areas.
- Reduced randomness in connectivity between cognitive and default mode domains was observed in schizophrenia.
- Increased randomness in default mode-sensorial area connectivity was found in schizophrenia patients.
Conclusions:
- Schizophrenia is associated with widespread alterations in functional connectivity strength and patterns across brain domains.
- Observed changes in connectivity randomness suggest complex, potentially deleterious, rewiring trade-offs among brain networks in schizophrenia.
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