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Updated: Jan 21, 2026

Measuring Bone Remodeling and Recreating the Tumor-Bone Microenvironment Using Calvaria Co-culture and Histomorphometry
Published on: March 14, 2020
Modulatory Effects of Plant Polyphenols on Bone Remodeling: A Prospective View From the Bench to Bedside
Vanessa Nicolin1, Nunziatina De Tommasi2, Stefania Lucia Nori2
1Clinical Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy.
Abstract:
During the past, a more comprehensive knowledge of mechanisms implicated in bone resorption processes has driven researchers to develop a compound library of many small molecules that specifically interfere with the genesis of osteoclast precursors cells. Natural compounds that suppress osteoclast commitment may have therapeutic value in treating pathologies associated with bone resorption like osteoporosis, rheumatoid arthritis, bone metastasis, and periodontal disease. The present review is focused on the current knowledge on the polyphenols derived from plants that could be efficacious in suppressing osteoclast differentiation and bone resorption.
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