Related Experiment Video
Updated: Jan 21, 2026
10:49
Doxycycline Loaded Collagen-Chitosan Composite Scaffold for the Accelerated Healing of Diabetic Wounds
Published on: August 21, 2021
4.9K
ERβ Accelerates Diabetic Wound Healing by Ameliorating Hyperglycemia-Induced Persistent Oxidative Stress
Xueqing Zhou1,2, Min Li2, Meifang Xiao3
1Department of General Surgery, Zhongnan Hospital of Wuhan University, Wuhan, China.
Frontiers in Endocrinology
|August 10, 2019
Summary
Diabetic wound healing is impaired by persistent oxidative stress. Activating ERβ (estrogen receptor beta) reduces this stress and accelerates healing, offering a new clinical strategy.
Area of Science:
- Biomedical Science
- Endocrinology
- Wound Healing Research
Background:
- Delayed wound healing is a significant complication in diabetic patients.
- The underlying mechanisms of impaired diabetic wound healing require further elucidation.
- Effective clinical strategies for diabetic wound management are urgently needed.
Purpose of the Study:
- To investigate the mechanisms behind persistent oxidative stress in diabetic wound healing.
- To explore the role of estrogen receptor beta (ERβ) in regulating oxidative stress.
- To evaluate ERβ activation as a potential therapeutic strategy for diabetic wound healing.
Main Methods:
- Human umbilical endothelial cells were exposed to high glucose conditions.
- Analysis included reactive oxygen species (ROS) generation, gene expression, and VEGF signaling.
- Diabetic rat wound models were used to assess healing rates with ERβ modulators and MnTBAP.
Main Results:
- Transient hyperglycemia induced persistent ROS overgeneration and suppressed ERβ and SOD2 expression.
- ERβ activation diminished ROS generation and accelerated wound healing in diabetic rats.
- ERβ activation effectively breaks the positive-feedback loop of oxidative stress.
Conclusions:
- ERβ activation ameliorates hyperglycemia-induced persistent oxidative stress, accelerating diabetic wound healing.
- ERβ plays a crucial role in mitigating oxidative stress in diabetic complications.
- Targeting ERβ represents a promising novel therapeutic approach for diabetic wound treatment.
More Related Videos
08:06Creation and Transplantation of an Adipose-derived Stem Cell ASC Sheet in a Diabetic Wound-healing Model
Published on: August 4, 2017
11.8K
13:35Acute and Chronic Models of Hyperglycemia in Zebrafish: A Method to Assess the Impact of Hyperglycemia on Neurogenesis and the Biodistribution of Radiolabeled Molecules
Published on: June 26, 2017
13.9K
Related Concept Videos
03:14Oxidation Numbers
42.2K
In redox reactions, the transfer of electrons occurs between reacting species. Electron transfer is described by a hypothetical number called the oxidation number (or oxidation state). It represents the effective charge of an atom or element, which is assigned using a set of rules.
42.2K
01:17Accelerators
277
Accelerators in concrete serve as admixtures to speed up the hardening process, enabling the concrete to achieve early strength faster. Although accelerators do not necessarily impact the time it takes concrete to set, they reduce this time in practice. A common accelerator is calcium chloride, which is particularly useful for hastening early strength development in cold weather or for rapid repair jobs that require quick heat generation after mixing.
The effectiveness of calcium chloride can...
The effectiveness of calcium chloride can...
277
01:17Accelerating Fluids
2.3K
When a fluid is in constant acceleration, the pressure and buoyant force equations are modified. Suppose a beaker is placed in an elevator accelerating upward with a constant acceleration, a. In the beaker, assume there is a thin cylinder of height h with an infinitesimal cross-sectional area, ΔS.
The motion of the liquid within this infinitesimal cylinder is considered to obtain the pressure difference. Three vertical forces act on this liquid:
The motion of the liquid within this infinitesimal cylinder is considered to obtain the pressure difference. Three vertical forces act on this liquid:
2.3K
01:16Instantaneous Acceleration
22.7K
Acceleration is in the direction of the change in velocity, but it is not always in the direction of motion. When an object slows down, its acceleration is opposite to the direction of its motion. Although commonly referred to as deceleration, this causes confusion in our analysis as deceleration is not a vector, and does not point to a specific direction with respect to a coordinate system. Therefore, the term deceleration is not used. For example, when a subway train slows down, it...
22.7K
01:30Acceleration Vectors
21.7K
In everyday conversation, accelerating means speeding up. Acceleration is a vector in the same direction as the change in velocity, Δv, therefore the greater the acceleration, the greater the change in velocity over a given time. Since velocity is a vector, it can change in magnitude, direction, or both. Thus acceleration is a change in speed or direction, or both. For example, if a runner traveling at 10 km/h due east slows to a stop, reverses direction, and continues their run at 10 km/h...
21.7K
01:15Pyruvate Oxidation
168.4K
After glycolysis, the charged pyruvate molecules enter the mitochondria via active transport and undergo three enzymatic reactions. These reactions ensure that pyruvate can enter the next metabolic pathway so that energy stored in the pyruvate molecules can be harnessed by the cells.
First, the enzyme pyruvate dehydrogenase removes the carboxyl group from pyruvate and releases it as carbon dioxide. The stripped molecule is then oxidized and releases electrons, which are then picked up by NAD+...
First, the enzyme pyruvate dehydrogenase removes the carboxyl group from pyruvate and releases it as carbon dioxide. The stripped molecule is then oxidized and releases electrons, which are then picked up by NAD+...
168.4K