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Comparison of CD8+ T Cell Accumulation in the Brain During Human and Murine Cerebral Malaria

Valentina Barrera1, Michael J Haley2, Patrick Strangward2

  • 1Department of Eye and Vision Science, University of Liverpool, Liverpool, United Kingdom.

Frontiers in Immunology
|August 10, 2019
PubMed

Insights

CD8+ T cells are crucial in experimental cerebral malaria (ECM). This study contrasts CD8+ T cell brain accumulation in human cerebral malaria (HCM) and ECM, finding shared pathways but also distinct differences.

Area of Science:

  • Immunology
  • Neuroscience
  • Infectious Diseases

Background:

  • CD8+ T cells are implicated in experimental cerebral malaria (ECM) pathogenesis.
  • The role of CD8+ T cells in human cerebral malaria (HCM) remains poorly understood.

Purpose of the Study:

  • To directly compare CD8+ T cell brain accumulation in HCM and ECM.
  • To investigate similarities and differences in T cell responses between human and experimental models of cerebral malaria.

Main Methods:

  • Analysis of CD8+ T cell infiltration in brain tissue from human pediatric cerebral malaria cases.
  • Induction of experimental cerebral malaria in C57BL/6J mice using Plasmodium berghei ANKA.
  • Comparative analysis of intracerebral CD8+ T cell distribution and routes of entry.

Main Results:

  • Demonstrated similarities in CD8+ T cell accumulation within the brain in both HCM and ECM.
  • Identified a shared choroid plexus-meningeal pathway for CD8+ T cell entry into the brain in both models.
  • Revealed significant differences in the compartmentalization of CD8+ T cells within the cerebrovascular bed between HCM and ECM.

Conclusions:

  • CD8+ T cell responses in the brain show conserved features between human and experimental cerebral malaria.
  • The choroid plexus-meningeal route is a common pathway for T cell infiltration in cerebral malaria.
  • Differences in cerebrovascular CD8+ T cell compartmentalization may contribute to distinct pathologies in HCM and ECM.
Keywords:
CD8+ T cellsPlasmodium bergheiPlasmodium falciparumbraincerebral malaria

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