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Links between High-Sensitivity C-Reactive Protein and Pulse Wave Analysis in Middle-Aged Patients with Hypertension

Ioana Mozos1,2, Daniela Jianu3,4, Cristina Gug5

  • 1Department of Functional Sciences, "Victor Babes" University of Medicine and Pharmacy, 300173 Timisoara, Romania.

Disease Markers
|August 10, 2019
PubMed

Insights

Vitamin D deficiency and elevated hsCRP and LDL are common in hypertensive patients. High oxidized LDL correlates with pulse pressure amplification, while hsCRP predicts early arterial aging and increased pulse wave velocity.

Area of Science:

  • Cardiovascular Medicine
  • Biochemistry
  • Public Health

Background:

  • Arterial stiffness and arterial age are crucial prognostic indicators for cardiovascular health.
  • Understanding the relationship between biomarkers and arterial aging is vital for early intervention.

Purpose of the Study:

  • To assess vitamin D, hsCRP, LDL, and oxLDL levels in middle-aged hypertensive patients.
  • To investigate the association of these biomarkers with pulse wave velocity (PWV), central blood pressure, and early arterial aging (EAA).

Main Methods:

  • 56 middle-aged hypertensive and high normal blood pressure patients were studied.
  • Mobile-O-Graph was used to measure central/peripheral blood pressure, PWV, and arterial age.
  • Blood samples were analyzed for 25-hydroxy vitamin D3, hsCRP, LDL, and oxLDL.

Main Results:

  • Significant correlations were found between oxLDL and pulse pressure amplification.
  • hsCRP and LDL levels showed significant associations with PWV and EAA.
  • ROC analysis identified hsCRP as a sensitive and specific predictor of EAA and increased PWV.

Conclusions:

  • Vitamin D deficiency, elevated hsCRP, and LDL are prevalent in this patient group.
  • High oxidized LDL is linked to pulse pressure amplification.
  • hsCRP is a key predictor of arterial stiffness and early arterial aging in hypertensive individuals.

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