Related Experiment Video

Updated: Jan 21, 2026

Studying the Role of Alveolar Macrophages in Breast Cancer Metastasis
07:47

Studying the Role of Alveolar Macrophages in Breast Cancer Metastasis

Published on: June 26, 2016

10.2K

Roles of circular RNA in breast cancer: present and future

Zehuan Li1, Zhanghan Chen1, Guohua Hu1

  • 1Department of General Surgery, Zhongshan Hospital, Fudan University Shanghai 200032, China.

American Journal of Translational Research
|August 10, 2019
PubMed

Insights

Circular RNAs (circRNAs) show promise as biomarkers for breast cancer detection and prognosis. These stable molecules may offer new avenues for personalized breast cancer medicine.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Breast cancer remains a leading cause of mortality in women, necessitating novel diagnostic and therapeutic strategies.
  • Current treatments like surgery, endocrine therapy, and targeted therapy have limitations, highlighting the need for new biomarkers.
  • Circular RNAs (circRNAs) are stable RNA molecules with potential roles in cancer development and progression.

Purpose of the Study:

  • To review the oncogenic and anti-oncogenic roles of circRNAs in breast cancer.
  • To explore the potential of circRNAs as biomarkers for early detection, treatment, and prognosis.
  • To discuss the future directions for circRNA research in personalized breast cancer medicine.

Main Methods:

  • Literature review of studies investigating circRNAs in breast cancer.
  • Analysis of circRNA functions in carcinogenesis, metastasis, and chemoresistance.
  • Evaluation of circRNAs as potential diagnostic and prognostic biomarkers.

Main Results:

  • CircRNAs can regulate gene expression impacting breast cancer development, metastasis, and treatment resistance.
  • CircRNAs demonstrate potential as stable biomarkers for monitoring breast cancer progression.
  • Further investigation is needed into circRNA translation and diagnostic value, particularly in plasma exosomes.

Conclusions:

  • CircRNAs hold significant promise as biomarkers and therapeutic targets in breast cancer.
  • Engineered exosomes loaded with anti-oncogenic circRNAs may offer a novel approach to personalized breast cancer treatment.
  • Continued research into circRNA mechanisms and clinical applications is crucial for advancing breast cancer care.
Keywords:
CircRNAbreast cancerchemoresistanceexosomefusion-circRNAmetastasis

More Related Videos

Orthotopic Transplantation of Breast Tumors as Preclinical Models for Breast Cancer07:45

Orthotopic Transplantation of Breast Tumors as Preclinical Models for Breast Cancer

Published on: May 18, 2020

6.9K
Optimization of a Multiplex RNA-based Expression Assay Using Breast Cancer Archival Material11:12

Optimization of a Multiplex RNA-based Expression Assay Using Breast Cancer Archival Material

Published on: August 1, 2018

8.4K

Related Concept Videos

RNA Stability01:53

RNA Stability

Intact DNA strands can be found in fossils, while scientists sometimes struggle to keep RNA intact under laboratory conditions. The structural variations between RNA and DNA underlie the differences in their stability and longevity. Because DNA is double-stranded, it is inherently more stable. The single-stranded structure of RNA is less stable but also more flexible and can form weak internal bonds. Additionally, most RNAs in the cell are relatively short, while DNA can be up to 250 million...
35.6K
Deformation in a Circular Shaft01:10

Deformation in a Circular Shaft

One of the distinctive characteristics of circular shafts is their ability to maintain their cross-sectional integrity under torsion. In other words, each cross-section continues to exist as a flat, unaltered entity, simply rotating like a solid, rigid slab. To understand the distribution of shearing stress within such a shaft, consider a cylindrical section inside this circular shaft. This section has a length of L and a radius of R, with one end fixed. The radius of the cylindrical section is...
876
Types of RNA01:23

Types of RNA

Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
72.6K
Uniform Circular Motion01:14

Uniform Circular Motion

Uniform circular motion is a specific type of motion in which an object travels in a circle with a constant speed. For example, any point on a propeller spinning at a constant rate is undergoing uniform circular motion. The second, minute, and hour hands of a watch also undergo uniform circular motion. It is hard to believe that points on these rotating objects are actually accelerating, even though the rotation rate is constant. To understand this, we must analyze the motion in terms of...
21.6K
Non-uniform Circular Motion01:22

Non-uniform Circular Motion

In uniform circular motion, the particle executing circular motion has a constant speed, and the circle is at a fixed radius. However, not all circular motion occurs at a constant speed. A particle can travel in a circle and speed up or slow down, showing an acceleration in the direction of motion. In that case, the motion is called non-uniform circular motion, and an additional acceleration is introduced, which is in the direction tangential to the circle. 
For example, such...
9.5K
Dynamics of Circular Motion01:30

Dynamics of Circular Motion

An object undergoing circular motion, like a race car, is accelerating because it is changing the direction of its velocity. This centrally directed acceleration is called centripetal acceleration. This acceleration acts along the radius of the curved path (thus is also referred to as radial acceleration).
Any acceleration must be produced by some force. Therefore, any force or combination of forces can cause centripetal acceleration. A few examples include the tension in the rope on a...
23.3K