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Factors Associated with RANTES Concentration in Cardiovascular Disease Patients
Olga M Koper-Lenkiewicz1, Joanna Kamińska1, Anna Lisowska2
1Department of Clinical Laboratory Diagnostics, Medical University of Bialystok, Poland.
Insights
RANTES levels in cardiovascular disease patients correlate with age, sex, and hsCRP. RANTES, unlike CCL2, may indicate atherosclerotic lesions, suggesting it as a therapeutic target.
Area of Science:
- Cardiovascular Medicine
- Immunology
- Biochemistry
Background:
- Cardiovascular diseases (CVD) are a leading cause of mortality worldwide.
- Chemokines, such as RANTES and CCL2, play a role in inflammatory processes underlying atherosclerosis.
- Understanding the factors influencing chemokine levels is crucial for developing targeted therapies.
Purpose of the Study:
- To investigate the relationship between RANTES and CCL2 concentrations and various clinical parameters in Polish patients with cardiovascular disease.
- To determine the potential of RANTES and CCL2 as biomarkers for atherosclerosis.
Main Methods:
- Plasma concentrations of RANTES and CCL2 were measured using ELISA in 115 CVD patients and 25 controls.
- Linear regression analyses (univariate and multiple) were employed to assess correlations with demographic, clinical, and laboratory variables.
Main Results:
- RANTES levels were significantly higher in men and increased with age, hsCRP concentration, and CCL2 concentration.
- Multiple regression analysis confirmed these associations and revealed a positive correlation between RANTES and mean platelet volume (MPV).
- No statistically significant linear regression models were obtained for CCL2.
Conclusions:
- RANTES appears to be a more reliable indicator of atherosclerotic lesions than CCL2 due to lower variability.
- RANTES concentration should be interpreted in the context of patient's sex, age, hsCRP, CCL2 levels, and platelet hyperactivity.
- RANTES may represent a valuable therapeutic target in managing atherosclerotic processes.
Objective:
The aim of the study was to establish, by means of linear regressions analysis, whether RANTES and CCL2 have a relationship with age, sex, heart rate, ejection fraction, white blood cells count, monocyte count, platelet count, mean platelet volume, hsCRP concentration, creatinine and eGFR value, applied treatments, and coronary risk factors in polish cardiovascular disease patients.
Methods:
Plasma chemokines concentrations were measured by ELISA method (R&D Systems Europe Ltd., Abingdon, England) in 115 cardiovascular disease patients (83 myocardial infarction/AMI and 32 stable angina/SA) and in the control group (N=25).
Results:
Univariate linear regression analysis found that (1) for men mean RANTES plasma level is 1.56 times higher as compared to women; (2) if patient's age increases by 1 year, the mean RANTES concentration value increases by 1.4%; (3) if CCL2 concentration increases by 10 pg/mL, the mean RANTES concentration value increases by 3.3%; (4) if hsCRP concentration increases by 1 mg/L, the mean RANTES concentration value increases by 1.0%. By means of multiple linear regression analysis we found that (1) for men the mean plasma RANTES concentration value increases 1.89 times as compared to women; (2) if CCL2 concentration increases by 10 pg/mL, the mean RANTES concentration value increases by 3.4%; (3) if MPV increases by 1 fL, the mean RANTES concentration value increases by 12%, if other model parameters are fixed. For CCL2 we did not obtain statistically significant linear regression models.
Conclusion:
Due to high variability of obtained CCL2 concentrations, it seems that RANTES better reflects the presence of the atherosclerotic lesion than CCL2. RANTES as a marker of atherosclerotic process may be an important therapeutic target, and the assessment of RANTES concentration should be interpreted depending on patient's sex, age, platelet hyperactivity state, hsCRP, and CCL2 concentration.
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