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Updated: Jan 21, 2026

Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma
07:55

Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma

Published on: April 11, 2018

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[Is there a magic bullet for sarcomas? : Personalised treatment for maligant tumours of bone and soft tissue]

S Scheipl1, B Liegl-Atzwanger2, J Szkandera3

  • 1Univ.-Klinik für Orthopädie und Traumatologie, Medizinische Universität Graz, Auenbruggerplatz 5, 8036, Graz, Österreich. susanne.scheipl@medunigraz.at.

Der Orthopade
|August 10, 2019
PubMed
Abstract

Insights

Personalized cancer therapies target tumor-specific genetic alterations. While some targeted treatments exist for soft-tissue sarcomas, more research is needed for bone sarcomas and rare tumor subtypes.

Area of Science:

  • Oncology
  • Genetics
  • Pharmacology

Background:

  • Personalized tumor therapies target oncogenic addiction pathways.
  • Understanding genetic alterations is key for effective cancer treatment.

Purpose of the Study:

  • Review genetic alterations in bone and soft-tissue tumors.
  • Identify potential therapeutic targets for personalized medicine.
  • Summarize recent personalized treatment approaches.

Main Methods:

  • Literature review of genetic alterations and targeted therapies.
  • Analysis of current treatment strategies for bone and soft-tissue sarcomas.
  • Evaluation of clinical trial data for novel therapeutic agents.

Main Results:

  • Molecular diagnosis is crucial for tumor characterization.
  • Targeted therapies are limited for bone sarcomas; Denosumab offers symptomatic relief.
  • Imatinib is effective for specific gastrointestinal stromal tumors (GISTs) and dermatofibrosarcoma protuberans.
  • Ongoing trials evaluate kinase inhibitors and antibodies for soft-tissue sarcomas; Sorafenib shows promise for desmoid fibromatosis.

Conclusions:

  • Further research is needed to link sarcoma genetic alterations to tumorigenesis for personalized strategies.
  • Clinical trial designs require adaptation for ultra-rare tumors and subtypes.
Keywords:
Drug resistanceMolecular targeted therapyMonoclonal antibodiesOsteosarcomaTyrosine kinase inhibitor

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