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A microstructurally inspired constitutive model for skin mechanics.

Sheng Chen1, Aisling Ní Annaidh2,3, Sara Roccabianca4

  • 1Department of Mechanical Engineering, Michigan State University, 428 S. Shaw Lane Room 2463, East Lansing, MI, 48824, USA.

Biomechanics and Modeling in Mechanobiology
|August 10, 2019
PubMed
Summary
This summary is machine-generated.

Skin mechanical properties are linked to collagen structure. Location and orientation significantly affect skin

Keywords:
Constitutive modelHistologyMechanical propertiesMicrostructureSkin

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Area of Science:

  • Biomechanics
  • Materials Science
  • Dermatology

Background:

  • Skin's mechanical properties are crucial for its function.
  • Understanding the relationship between skin's microstructure and its mechanical behavior is essential for various applications.
  • Previous studies have explored skin mechanics, but a comprehensive model integrating microstructural data is needed.

Purpose of the Study:

  • To investigate the correlation between the mechanical properties and microstructural characteristics of rat back skin.
  • To analyze the influence of location, orientation, and sex on skin's mechanical parameters.
  • To develop and validate a microstructurally informed constitutive model for rat back skin.

Main Methods:

  • Quasi-static uniaxial tensile testing of rat back skin samples from various locations, orientations, and sexes.
  • Analysis of stress-stretch behavior and rupture data.
  • Histological evaluation of collagen fiber orientation distribution, relative content, and fiber straightness.
  • Development of a constitutive model incorporating microstructural data.

Main Results:

  • Significant effects of location and orientation on skin mechanical properties (initial slope, maximum slope, ultimate tensile strength, rupture stretch, toughness).
  • Higher relative collagen content observed in the lower (caudal) back compared to the upper (cranial) back.
  • The proposed constitutive model demonstrated good agreement with experimental tensile test data.

Conclusions:

  • Skin's mechanical behavior is significantly influenced by its microstructural composition, particularly collagen organization.
  • The developed constitutive model provides a robust framework for predicting skin mechanics based on microstructural features.
  • This study offers a comprehensive understanding of the interplay between skin's mechanical properties, microstructure, and constitutive modeling.