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Electronic Pill Bottles or Bidirectional Text Messaging to Improve Hypertension Medication Adherence (Way 2 Text): a
Shivan J Mehta1,2,3, Kevin G Volpp4,5,6,7, Andrea B Troxel8
1Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. shivan.mehta@uphs.upenn.edu.
Insights
Monitoring medication adherence with electronic pill bottles or text messages did not improve blood pressure control in hypertensive patients. These interventions did not significantly impact systolic blood pressure compared to usual care.
Area of Science:
- Cardiovascular Medicine
- Health Services Research
- Digital Health
Background:
- Poor medication adherence is a significant barrier to effective hypertension management.
- The clinical utility of monitoring adherence using digital tools remains unclear.
Purpose of the Study:
- To assess the impact of electronic pill bottles and bidirectional text messaging on hypertension control.
- To evaluate if adherence monitoring improves systolic blood pressure (BP).
Main Methods:
- A pragmatic randomized controlled trial involving 149 primary care patients with hypertension.
- Participants were assigned to usual care, electronic pill bottle monitoring, or bidirectional text messaging for 4 months.
- Systolic blood pressure change from baseline was the primary outcome measure.
Main Results:
- No significant difference in systolic blood pressure reduction was observed between the usual care group and either the electronic pill bottle group (p=0.94) or the text messaging group (p=1.00).
- The two intervention groups also showed no significant difference when compared to each other (p=0.93).
- Measured adherence was good, but did not translate to improved blood pressure control.
Conclusions:
- Neither electronic pill bottle feedback nor bidirectional text messaging effectively improved blood pressure control in this hypertensive patient cohort.
- Adherence monitoring via these methods may not be sufficient to overcome barriers to blood pressure control or may not address the primary drivers of uncontrolled hypertension.
Background:
Poor medication adherence contributes to inadequate control of hypertension. However, the value of adherence monitoring is unknown.
Objective:
To evaluate the impact of monitoring adherence with electronic pill bottles or bidirectional text messaging on improving hypertension control.
Design:
Three-arm pragmatic randomized controlled trial.
Patients:
One hundred forty-nine primary care patients aged 18-75 with hypertension and text messaging capabilities who were seen at least twice in the prior 12 months with at least two out-of-range blood pressure (BP) measurements, including the most recent visit.
Interventions:
Patients were randomized in a 1:2:2 ratio to receive (1) usual care, (2) electronic pill bottles for medication adherence monitoring (pill bottle), and (3) bidirectional text messaging for medication adherence monitoring (bidirectional text).
Main Measures:
Change in systolic BP during the final 4-month visit compared with baseline.
Key Results:
At the 4-month follow-up visit, mean (SD) change values in systolic blood pressure were - 4.7 (23.4) mmHg in usual care, - 4.3 (21.5) mmHg in the pill bottle arm, and - 4.6 (19.8) mmHg in the text arm. There was no significant change in systolic blood pressure between control and the pill bottle arm (p = 0.94) or the text messaging arm (p = 1.00), and the two intervention arms did not differ from each other (p = 0.93).
Conclusions:
Despite good measured adherence, neither feedback with electronic pill bottles nor bidirectional text messaging about medication adherence improved blood pressure control. Adherence to prescribed medications was not improved enough to affect BP control or it was not the primary driver of poor control.
Trial Registration:
clinicaltrials.gov (NCT02778542).
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