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Related Concept Videos

Accelerators01:17

Accelerators

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Accelerators in concrete serve as admixtures to speed up the hardening process, enabling the concrete to achieve early strength faster. Although accelerators do not necessarily impact the time it takes concrete to set, they reduce this time in practice. A common accelerator is calcium chloride, which is particularly useful for hastening early strength development in cold weather or for rapid repair jobs that require quick heat generation after mixing.
The effectiveness of calcium chloride can...
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Accelerating Fluids01:17

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When a fluid is in constant acceleration, the pressure and buoyant force equations are modified. Suppose a beaker is placed in an elevator accelerating upward with a constant acceleration, a. In the beaker, assume there is a thin cylinder of height h with an infinitesimal cross-sectional area, ΔS.
The motion of the liquid within this infinitesimal cylinder is considered to obtain the pressure difference. Three vertical forces act on this liquid:
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Instantaneous Acceleration01:16

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Acceleration is in the direction of the change in velocity, but it is not always in the direction of motion. When an object slows down, its acceleration is opposite to the direction of its motion. Although commonly referred to as deceleration, this causes confusion in our analysis as deceleration is not a vector, and does not point to a specific direction with respect to a coordinate system. Therefore, the term deceleration is not used. For example, when a subway train slows down, it...
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Acceleration Vectors01:30

Acceleration Vectors

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In everyday conversation, accelerating means speeding up. Acceleration is a vector in the same direction as the change in velocity, Δv, therefore the greater the acceleration, the greater the change in velocity over a given time. Since velocity is a vector, it can change in magnitude, direction, or both. Thus acceleration is a change in speed or direction, or both. For example, if a runner traveling at 10 km/h due east slows to a stop, reverses direction, and continues their run at 10 km/h...
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Average Acceleration01:30

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The importance of understanding acceleration spans our day-to-day experiences, as well as the vast reaches of outer space and the tiny world of subatomic physics. In everyday conversation, to accelerate means to speed up. For instance, we are familiar with the acceleration of our car; the harder we apply our foot to the gas pedal, the faster we accelerate. The greater the acceleration, the greater the change in velocity over a given time. Acceleration is widely seen in experimental physics. In...
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Measuring Acceleration Due to Gravity01:12

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Consider a coffee mug hanging on a hook in a pantry. If the mug gets knocked, it oscillates back and forth like a pendulum until the oscillations die out.
A simple pendulum can be described as a point mass and a string. Meanwhile, a physical pendulum is any object whose oscillations are similar to a simple pendulum, but cannot be modeled as a point mass on a string because its mass is distributed over a larger area. The behavior of a physical pendulum can be modeled using the principles of...
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Related Experiment Video

Updated: Jan 21, 2026

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides
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Google-Accelerated Biomolecular Simulations.

Kai J Kohlhoff1

  • 1Research, Google, Mountain View, CA, USA. kohlhoff@google.com.

Methods in Molecular Biology (Clifton, N.J.)
|August 10, 2019
PubMed
Summary
This summary is machine-generated.

Cloud computing offers an efficient alternative for biomolecular simulations, simplifying complex tasks like modeling and analysis. Utilizing Google Cloud Platform with GROMACS and Docker containers enhances reproducibility and accessibility for researchers.

Keywords:
Cloud computingDistributed computingLarge-scale simulation

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Area of Science:

  • Computational Biology
  • Biomolecular Simulations
  • Cloud Computing

Background:

  • Biomolecular simulations require significant computational resources, traditionally accessed via local infrastructure or supercomputing centers.
  • Cloud computing presents a scalable, on-demand alternative for computational tasks in scientific research.
  • Recent advancements facilitate easier cloud configuration for scientific workloads.

Purpose of the Study:

  • To demonstrate the use of Google Cloud Platform for biomolecular simulations.
  • To provide a practical guide for researchers to leverage cloud resources.
  • To highlight the benefits of cloud computing for scientific reproducibility and collaboration.

Main Methods:

  • Utilizing Google Cloud Platform for computational tasks.
  • Employing the GROningen MAchine for Chemical Simulations (GROMACS) package.
  • Leveraging Docker containers for virtualization and cloud storage for data management.

Main Results:

  • Successful configuration and execution of biomolecular simulations on Google Cloud.
  • Demonstration of simplified job submission and resource scaling.
  • Validation of Docker containers and cloud storage for reproducible research.

Conclusions:

  • Google Cloud Platform provides a viable and efficient environment for biomolecular simulations.
  • The use of Docker containers and cloud storage addresses key challenges in research reproducibility and data sharing.
  • The methods presented are transferable to a wide range of scientific computing tasks.