Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Growth Models with Integration: Problem Solving01:27

Growth Models with Integration: Problem Solving

31
In population modeling, integration provides a systematic way to determine accumulated quantities from known rates of change. One such application arises in ecology, where the total weight of a fish population in a body of water is referred to as its biomass. When the rate of growth of this biomass is known as a function of time, calculus can be used to determine the total biomass at a future date.Growth Rate and Biomass FunctionLet the growth rate of the fish population be represented by a...
31
The Fluid Mosaic Model01:34

The Fluid Mosaic Model

177.3K
The fluid mosaic model was first proposed as a visual representation of research observations. The model comprises the composition and dynamics of membranes and serves as a foundation for future membrane-related studies. The model depicts the structure of the plasma membrane with a variety of components, which include phospholipids, proteins, and carbohydrates. These integral molecules are loosely bound, defining the cell’s border and providing fluidity for optimal function.
177.3K
The Quantum-Mechanical Model of an Atom02:45

The Quantum-Mechanical Model of an Atom

56.6K
Shortly after de Broglie published his ideas that the electron in a hydrogen atom could be better thought of as being a circular standing wave instead of a particle moving in quantized circular orbits, Erwin Schrödinger extended de Broglie’s work by deriving what is now known as the Schrödinger equation. When Schrödinger applied his equation to hydrogen-like atoms, he was able to reproduce Bohr’s expression for the energy and, thus, the Rydberg formula governing hydrogen spectra.
56.6K
Molecular Models02:00

Molecular Models

43.6K
Physical models representing molecular architectures of chemical compounds play essential roles in understanding chemistry. The use of molecular models makes it easier to visualize the structures and shapes of atoms and molecules.
43.6K
Protein Complex Assembly02:41

Protein Complex Assembly

16.7K
Proteins can form homomeric complexes with another unit of the same protein or heteromeric complexes with different types.  Most protein complexes self-assemble spontaneously via ordered pathways, while some proteins need assembly factors that guide their proper assembly. Despite the crowded intracellular environment, proteins usually interact with their correct partners and form functional complexes.
Many viruses self-assemble into a fully functional unit using the infected host cell to...
16.7K
What is Conservation Biology?01:57

What is Conservation Biology?

24.0K
Conservation biology is a scientific field that focuses on the preservation of biodiversity in order to protect ecosystems while meeting the needs of the human population. Humans require properly functioning ecosystems to maintain our supply of natural resources, including food, medicines, and building materials.
24.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Extending structural surfaceomics to identify aberrant conformations of tumor surface proteins as potential immunotherapy targets.

bioRxiv : the preprint server for biology·2026
Same author

Coronavirus protein interaction mapping in bat and human cells reveals network rewiring governing immune evasion and zoonotic potential.

Cell host & microbe·2026
Same author

Systematic discovery of pro- and anti-HIV host factors in primary human CD4+ T cells.

Cell·2026
Same author

The scientific legacy of Martin Karplus from the perspective of his collaborators.

Biophysical journal·2026
Same author

Interpreting chemical crosslinks: Score-based approaches and deep neural networks.

Current opinion in structural biology·2026
Same author

The filamentous ultrastructure of the PopZ condensate is required for its cellular function.

Nature structural & molecular biology·2026
Same journal

Mapping the 3D Chromosome Organization of a Biosynthetic Gene Cluster by Capture Hi-C (CHi-C).

Methods in molecular biology (Clifton, N.J.)·2026
Same journal

Mapping the 3D Chromosome Organization of Streptomyces by Hi-C.

Methods in molecular biology (Clifton, N.J.)·2026
Same journal

CUT&Tag Epigenomic Profiling of Biosynthetic Gene Clusters in Arabidopsis thaliana.

Methods in molecular biology (Clifton, N.J.)·2026
Same journal

Rhizobium rhizogenes-Mediated Hairy Root Transformation Protocol for Lotus japonicus and Other Legumes.

Methods in molecular biology (Clifton, N.J.)·2026
Same journal

Characterization of Bioactive Saponins from Sea Cucumbers.

Methods in molecular biology (Clifton, N.J.)·2026
Same journal

Methods for Functional Validation of Terpenoid Metabolic Clusters in Nicotiana benthamiana and Aspergillus oryzae.

Methods in molecular biology (Clifton, N.J.)·2026
See all related articles

Related Experiment Video

Updated: Jan 21, 2026

The MultiBac Protein Complex Production Platform at the EMBL
13:51

The MultiBac Protein Complex Production Platform at the EMBL

Published on: July 11, 2013

16.6K

Modeling Biological Complexes Using Integrative Modeling Platform.

Daniel Saltzberg1, Charles H Greenberg1, Shruthi Viswanath1

  • 1California Institute for Quantitative Biosciences, University of California, San Francisco, CA, USA.

Methods in Molecular Biology (Clifton, N.J.)
|August 10, 2019
PubMed
Summary
This summary is machine-generated.

This study demonstrates integrative structure modeling for protein assemblies using multiple experimental data types. The Integrative Modeling Platform (IMP) software facilitates building accurate 3D models of complex biomolecular systems.

Keywords:
Biomolecular simulationBiophysical dataIntegrative modelingStructural modeling

More Related Videos

A Rat Model of Central Fatigue Using a Modified Multiple Platform Method
05:13

A Rat Model of Central Fatigue Using a Modified Multiple Platform Method

Published on: August 14, 2018

9.6K
Integrated Compensatory Responses in a Human Model of Hemorrhage
07:57

Integrated Compensatory Responses in a Human Model of Hemorrhage

Published on: November 20, 2016

13.1K

Related Experiment Videos

Last Updated: Jan 21, 2026

The MultiBac Protein Complex Production Platform at the EMBL
13:51

The MultiBac Protein Complex Production Platform at the EMBL

Published on: July 11, 2013

16.6K
A Rat Model of Central Fatigue Using a Modified Multiple Platform Method
05:13

A Rat Model of Central Fatigue Using a Modified Multiple Platform Method

Published on: August 14, 2018

9.6K
Integrated Compensatory Responses in a Human Model of Hemorrhage
07:57

Integrated Compensatory Responses in a Human Model of Hemorrhage

Published on: November 20, 2016

13.1K

Area of Science:

  • Structural Biology
  • Computational Biology
  • Biophysics

Background:

  • Macromolecular assemblies are crucial for cellular functions.
  • Determining the 3D structure of large protein complexes is challenging.
  • Integrative modeling combines diverse experimental data for structural insights.

Purpose of the Study:

  • To provide a practical example of integrative structure modeling for a specific protein assembly.
  • To showcase the application of the Integrative Modeling Platform (IMP) software.
  • To guide users in applying IMP for other biomolecular systems.

Main Methods:

  • Utilized electron microscopy, X-ray scattering, and chemical crosslinking data.
  • Integrated subunit structural information and physical constraints.
  • Employed a four-stage integrative modeling process: data gathering, representation and scoring, sampling, and analysis.
  • Leveraged the open-source Integrative Modeling Platform (IMP) and its Python Modeling Interface (PMI).

Main Results:

  • Successfully modeled the quaternary structure of the actin, tropomyosin, and gelsolin complex.
  • Demonstrated the flexibility and power of IMP for combining various data types.
  • Provided a validated workflow for generating and analyzing integrative models.

Conclusions:

  • Integrative structure modeling is a powerful approach for elucidating complex biomolecular structures.
  • IMP offers a comprehensive toolkit for researchers to perform integrative modeling.
  • The study facilitates the deposition of integrative structures into PDB-Dev for broader accessibility.