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Updated: Jan 21, 2026

Electrophysiological Recordings from the Giant Fiber Pathway of D. melanogaster
Published on: January 14, 2011
Coarse Graining of a Giant Molecular System: The Chromatin Fiber
1Department of Physics and Center for Complexity and Biosystems, Università Degli Studi di Milano and INFN, Milan, Italy.
Abstract:
The chromatin fiber is a complex polymer whose conformational properties are quite important to regulate gene transcription. One cannot but resort to coarse-grained models to describe the structure and the dynamics of this system on the length scale of the cellular nucleus. Bulk biological data can be used within the framework of the principle of maximum entropy to generate a realistic interaction potential that can be used to sample the equilibrium state of the fiber. The analysis of the structure and of the dynamics of the fiber can be correlated with its biological function, thus providing interesting results about transcriptional regulation.
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