Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Antigen Presenting Cells01:22

Antigen Presenting Cells

3.0K
The immune system is a complex network of cells and molecules that protects the body from foreign invaders. T cells, a type of white blood cell, play a crucial role in this process. They recognize and attack foreign substances, such as pathogens, that enter the body.
T cells require the help of antigen-presenting cells (APCs), which process foreign antigens into smaller fragments that can be recognized by T cells. These APCs are highly specialized cells that efficiently internalize antigens...
3.0K
Cell Specific Gene Expression01:58

Cell Specific Gene Expression

16.3K
Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...
16.3K
Cell Specific Gene Expression01:58

Cell Specific Gene Expression

5.4K
5.4K
Diversity of Antigen Receptors01:28

Diversity of Antigen Receptors

1.4K
Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
1.4K
Antigen Processing Pathways01:31

Antigen Processing Pathways

2.1K
MHC molecules are key players in the immune response, enabling T cells to recognize and respond to specific antigens. They are present on the surface of all nucleated cells in the body and are instrumental in presenting antigens to T cells and activating them. T cells recognize the MHC-antigen complex and initiate an immune response. MHC class I and MHC class II are two main types of MHC molecules, each associated with a distinct antigen processing pathway.
MHC Class I: Presenting Endogenous...
2.1K
Specific Heat01:16

Specific Heat

67.2K
The specific heat capacity of a substance refers to the energy required to increase the temperature of one gram of that substance by one degree Celcius. Specific heat capacity is often represented in calories (cal), grams (g), and degrees Celsius (oC), but can also be expressed in joules (J), kilograms (kg), and Kelvin (K), among other units.
For example, increasing the temperature of one gram of water by 1°C requires one calorie of heat energy and can be written as 1 cal/g-°C, or...
67.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Beta-Adrenergic Stimulation and <i>MYH7</i> G256E Mutant Gene Dosage Drive Hypertrophic Cardiomyopathy Phenotype Penetrance.

bioRxiv : the preprint server for biology·2026
Same author

Xenophagocytosis blockade enhances interspecies chimerism.

Cell·2026
Same author

Restoration of the immune system with base editing and non-genotoxic conditioning in a Rag2 point-mutant mouse model.

Molecular therapy : the journal of the American Society of Gene Therapy·2026
Same author

Dual-antigen recognition iPSC-derived CAR-T cells for B-cell malignancies: establishment of a COVID-19 vaccine synergy strategy.

Frontiers in cell and developmental biology·2026
Same author

In vivo CRISPR screening identifies SAGA complex members as key regulators of hematopoiesis.

Nature communications·2026
Same author

Xenophagocytosis blockade enhances interspecies chimerism.

bioRxiv : the preprint server for biology·2025

Related Experiment Video

Updated: Jan 21, 2026

Using Human Induced Pluripotent Stem Cells for the Generation of Tumor Antigen-specific T Cells
10:57

Using Human Induced Pluripotent Stem Cells for the Generation of Tumor Antigen-specific T Cells

Published on: October 24, 2019

10.9K

Human iPSC Generation from Antigen-Specific T Cells.

Toshinobu Nishimura1, Yukiko Murmann1, Hiromitsu Nakauchi2

  • 1Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA.

Methods in Molecular Biology (Clifton, N.J.)
|August 10, 2019
PubMed
Summary

Induced pluripotent stem cells (iPSCs) offer a solution to T cell exhaustion in adoptive T cell immunotherapy. Reprogramming and redifferentiating T cells may enhance cancer treatment efficacy.

Keywords:
Cancer immunotherapyPluripotent stem cellT cell

More Related Videos

Generating De Novo Antigen-specific Human T Cell Receptors by Retroviral Transduction of Centric Hemichain
08:48

Generating De Novo Antigen-specific Human T Cell Receptors by Retroviral Transduction of Centric Hemichain

Published on: October 25, 2016

9.0K
Killer Artificial Antigen Presenting Cells KaAPC for Efficient In Vitro Depletion of Human Antigen-specific T Cells
08:12

Killer Artificial Antigen Presenting Cells KaAPC for Efficient In Vitro Depletion of Human Antigen-specific T Cells

Published on: August 11, 2014

10.0K

Related Experiment Videos

Last Updated: Jan 21, 2026

Using Human Induced Pluripotent Stem Cells for the Generation of Tumor Antigen-specific T Cells
10:57

Using Human Induced Pluripotent Stem Cells for the Generation of Tumor Antigen-specific T Cells

Published on: October 24, 2019

10.9K
Generating De Novo Antigen-specific Human T Cell Receptors by Retroviral Transduction of Centric Hemichain
08:48

Generating De Novo Antigen-specific Human T Cell Receptors by Retroviral Transduction of Centric Hemichain

Published on: October 25, 2016

9.0K
Killer Artificial Antigen Presenting Cells KaAPC for Efficient In Vitro Depletion of Human Antigen-specific T Cells
08:12

Killer Artificial Antigen Presenting Cells KaAPC for Efficient In Vitro Depletion of Human Antigen-specific T Cells

Published on: August 11, 2014

10.0K

Area of Science:

  • Stem cell biology
  • Immunotherapy
  • Cancer research

Background:

  • Induced pluripotent stem cells (iPSCs) provide a versatile tool for research and clinical applications, circumventing ethical and immunological issues associated with embryonic stem cells.
  • Adoptive T cell immunotherapy shows promise but is limited by T cell exhaustion during expansion, reducing treatment effectiveness.

Purpose of the Study:

  • To explore the potential of rejuvenating exhausted T cells through reprogramming to pluripotency and subsequent redifferentiation.
  • To investigate a novel therapeutic strategy for improving the efficacy of T cell-based cancer treatments.

Main Methods:

  • Reprogramming of T cells to induced pluripotent stem cells (iPSCs).
  • Redifferentiation of reprogrammed cells back into functional T cells.
  • Assessment of rejuvenated T cell function and potential for therapeutic application.

Main Results:

  • Successfully reprogrammed T cells to a pluripotent state.
  • Demonstrated redifferentiation of iPSCs into functional T cells.
  • Indicated potential for overcoming T cell exhaustion.

Conclusions:

  • T cell reprogramming to pluripotency and redifferentiation offers a promising strategy to rejuvenate exhausted T cells.
  • This approach could enhance the effectiveness of adoptive T cell immunotherapy for various cancers.
  • iPSC technology presents a novel avenue for developing advanced cancer therapies.