Related Experiment Video
Updated: Jan 21, 2026

In Silico Clinical Trials for Cardiovascular Disease
Published on: May 27, 2022
Reducing cardiovascular disease in a rural community
Sallie D Allgood1, Jennifer Leeman1,2, Cherie A Rosemond3,4
1School of Nursing, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
This study adapted a cardiovascular disease (CVD) prevention program using community health workers (CHWs) for a rural African-American community. Community engagement ensured the intervention met local needs and preferences.
Area of Science:
- Public Health
- Health Disparities
- Community-Based Interventions
Background:
- Cardiovascular disease (CVD) prevention requires tailored interventions for diverse populations.
- Evidence-based interventions often need adaptation for specific community contexts.
- Rural, African-American communities face unique challenges in accessing CVD prevention resources.
Purpose of the Study:
- To adapt an existing evidence-based CVD prevention intervention for a rural, predominantly African-American community.
- To engage community partners throughout the adaptation process.
- To ensure the intervention's content, materials, and delivery methods align with community needs and preferences.
Main Methods:
- A community-engaged formative research phase guided the adaptation process.
- A framework for adapting evidence-based interventions was utilized.
- Stakeholder engagement involved assessing intervention fit and iteratively adapting components.
Main Results:
- Community input informed the adaptation of intervention content, materials, and delivery.
- CHW roles, workflows, and training plans were developed based on formative findings.
- The adapted intervention was tailored to the specific needs and resources of the target community.
Conclusions:
- Community-engaged formative work is crucial for adapting evidence-based interventions.
- Successful adaptation enhances intervention relevance and potential effectiveness in specific populations.
- This approach can improve CVD prevention efforts in underserved rural communities.
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