Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Test for Homogeneity01:23

Test for Homogeneity

2.4K
The goodness–of–fit test can be used to decide whether a population fits a given distribution, but it will not suffice to decide whether two populations follow the same unknown distribution. A different test, called the test for homogeneity, can be used to conclude whether two populations have the same distribution. To calculate the test statistic for a test for homogeneity, follow the same procedure as with the test of independence. The hypotheses for the test for homogeneity can...
2.4K
Homogeneous Equilibria for Gaseous Reactions02:15

Homogeneous Equilibria for Gaseous Reactions

28.8K
Homogeneous Equilibria for Gaseous Reactions
For gas-phase reactions, the equilibrium constant may be expressed in terms of either the molar concentrations (Kc) or partial pressures (Kp) of the reactants and products. A relation between these two K values may be simply derived from the ideal gas equation and the definition of molarity. According to the ideal gas equation:
28.8K
Tissue Homogenization and Cell Lysis01:32

Tissue Homogenization and Cell Lysis

10.0K
Tissue homogenization involves disintegrating tissue architecture and lysing cells, and is an early step in isolating and analyzing cellular components. The method used for homogenization depends on the sample type, the amount of sample available, the analyte to be obtained, and the sensitivity of the method. These methods are broadly classified as mechanical and non-mechanical methods.
Mechanical methods of tissue homogenization
These methods rely on applying external physical force to disrupt...
10.0K
Colors and Magnetism03:02

Colors and Magnetism

14.0K
Color in Coordination Complexes
When atoms or molecules absorb light at the proper frequency, their electrons are excited to higher-energy orbitals. For many main group atoms and molecules, the absorbed photons are in the ultraviolet range of the electromagnetic spectrum, which cannot be detected by the human eye. For coordination compounds, the energy difference between the d orbitals often allows photons in the visible range to be absorbed and emitted, which is seen as colors by the human...
14.0K
Magnetism01:30

Magnetism

8.4K
Magnets are commonly found in everyday objects, such as toys, hangers, elevators, doorbells, and computer devices. Experimentation on these magnets shows that all magnets have two poles: one is labeled north (N) and the other south (S). Magnetic poles repel if they are alike and attract if unlike. Moreover, both poles of a magnet attract unmagnetized pieces of iron.
An individual magnetic pole cannot be isolated. No matter how small, every piece of a magnet contains a north pole and a south...
8.4K
Cellular Differentiation00:57

Cellular Differentiation

5.1K
How does a complex organism such as a human develop from a single cell? It all starts from a single fertilized egg which gives rise to a vast array of cell types, such as nerve cells, muscle cells, and epithelial cells that characterize the adult? Throughout development and adulthood, cellular differentiation leads cells to assume their final morphology and physiology. Differentiation is the process by which unspecialized cells become specialized to carry out distinct functions.
A zygote is a...
5.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Electron-phonon coupling and symmetry breaking in superconducting oxide interfaces near ferroelectric quantum criticality.

Nature materials·2026
Same author

Fast hydrated-ion transport and desolvation in pyridinyl COF membranes <i>via</i> competitive coordination.

Chemical science·2026
Same author

Seasonal variation in childhood acute lymphoblastic leukemia, but not in acute myeloid leukemia, or brain tumors - A Swedish population-based study.

Cancer epidemiology·2026
Same author

Haagerup Symmetry in (E_{8})_{1}?

Physical review letters·2026
Same author

Human versus GPT-4 in qualitative analysis: A comparative reanalysis of patient interview data following anterior cruciate ligament injury rehabilitation.

The Knee·2026
Same author

Tailoring Biomass-Derived Organosolv Lignin Derivatives for High-Capacity Adsorption of Rhodamine B.

ChemSusChem·2026

Related Experiment Video

Updated: Jan 21, 2026

Rapid Homogeneous Detection of Biological Assays Using Magnetic Modulation Biosensing System
06:58

Rapid Homogeneous Detection of Biological Assays Using Magnetic Modulation Biosensing System

Published on: June 13, 2010

10.0K

Homogeneous Differential Magnetic Assay.

Sobhan Sepehri, Teresa Zardán Gómez de la Torre1, Justin F Schneiderman2

  • 1The Ångström Laboratory, Department of Engineering Sciences , Uppsala University , Box 534, SE-751 21 Uppsala , Sweden.

ACS Sensors
|August 10, 2019
PubMed
Summary
This summary is machine-generated.

A novel homogeneous differential magnetic assay offers sensitive detection of low target concentrations without amplification. This rapid point-of-care diagnostic method overcomes limitations of traditional homogeneous assays.

Keywords:
Brownian relaxationbinding kineticshomogeneous differential magnetic assaymagnetic nanoparticlerolling circle amplificationvolumetric detection

More Related Videos

Author Spotlight: Development of a Large-Scale, Reproducible Production Method for Exosome Mimetics Using Magnetic Nanoparticles
05:36

Author Spotlight: Development of a Large-Scale, Reproducible Production Method for Exosome Mimetics Using Magnetic Nanoparticles

Published on: January 26, 2024

1.9K
Studies of Chaperone-Cochaperone Interactions using Homogenous Bead-Based Assay
06:51

Studies of Chaperone-Cochaperone Interactions using Homogenous Bead-Based Assay

Published on: July 21, 2021

3.2K

Related Experiment Videos

Last Updated: Jan 21, 2026

Rapid Homogeneous Detection of Biological Assays Using Magnetic Modulation Biosensing System
06:58

Rapid Homogeneous Detection of Biological Assays Using Magnetic Modulation Biosensing System

Published on: June 13, 2010

10.0K
Author Spotlight: Development of a Large-Scale, Reproducible Production Method for Exosome Mimetics Using Magnetic Nanoparticles
05:36

Author Spotlight: Development of a Large-Scale, Reproducible Production Method for Exosome Mimetics Using Magnetic Nanoparticles

Published on: January 26, 2024

1.9K
Studies of Chaperone-Cochaperone Interactions using Homogenous Bead-Based Assay
06:51

Studies of Chaperone-Cochaperone Interactions using Homogenous Bead-Based Assay

Published on: July 21, 2021

3.2K

Area of Science:

  • Biomagnetic assays
  • Point-of-care diagnostics
  • Microfluidics

Background:

  • Homogeneous assays are valuable for point-of-care diagnostics due to their simplified workflow.
  • Limitations in current homogeneous assays include slow kinetics, amplification needs, and high background noise, hindering sensitivity at low target concentrations.
  • Existing methods struggle with detecting very low concentrations of pathogens, drugs, or toxins efficiently.

Purpose of the Study:

  • To develop a homogeneous assay that overcomes the speed and sensitivity limitations of existing methods.
  • To enable rapid and highly sensitive detection of low target concentrations without amplification.
  • To advance point-of-care diagnostic capabilities.

Main Methods:

  • Development of a homogeneous differential magnetic assay utilizing a differential magnetic readout.
  • Integration of a gradiometer sensor configuration with precise microfluidic sample handling.
  • Simultaneous differential measurement of positive and negative control samples.

Main Results:

  • The assay successfully eliminates limitations of previous homogeneous assays by reducing background signal and increasing readout speed.
  • Detection of very low target concentrations down to femtomolar levels was achieved without additional amplification.
  • Demonstrated high sensitivity and speed suitable for point-of-care applications.

Conclusions:

  • The homogeneous differential magnetic assay provides a novel approach for rapid and highly sensitive diagnostics.
  • This method significantly enhances the detection capabilities for low concentrations of various targets.
  • Opens new possibilities for advanced point-of-care diagnostic tools.