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Updated: Jan 21, 2026
08:50
Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
16.7K
Summary
Chronic kidney disease (CKD) is a common complication in HIV patients. Early detection and access to antiretroviral therapy (ART) improve kidney function, survival rates for dialysis, and transplant outcomes.
Area of Science:
- Nephrology
- Infectious Diseases
- HIV Medicine
Background:
- Chronic kidney disease (CKD) is a significant complication of HIV infection.
- HIV-associated nephropathy (HIVAN) and HIV-immune complex disease are key renal manifestations.
- The advent of antiretroviral therapy (ART) has altered the landscape of HIVAN, increasing focal segmental glomerulosclerosis prevalence.
Purpose of the Study:
- To review the impact of HIV infection on kidney health.
- To discuss the role of antiretroviral therapy (ART) in managing HIV-related kidney disease.
- To highlight the importance of early detection and management strategies for CKD in HIV-positive individuals.
Main Methods:
- Literature review of studies on HIV and kidney disease.
- Analysis of the effects of ART on renal function in HIV patients.
- Examination of outcomes for HIV-positive patients undergoing dialysis or kidney transplantation.
Main Results:
- ART has led to a decline in HIVAN incidence and improved overall kidney function.
- HIV-positive patients on ART show comparable survival rates on dialysis and successful outcomes with kidney transplantation.
- Many antiretroviral drugs require dose adjustment in patients with CKD.
Conclusions:
- Early screening for kidney disease upon HIV diagnosis and annually is crucial.
- Access to ART and preventative HIV programs are essential for reducing the burden of CKD in HIV.
- Kidney transplantation and dialysis are viable options for HIV-positive patients with advanced kidney disease.
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