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Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

16.7K

HIV/AIDS and chronic kidney disease

Saraladevi Naicker

    Clinical Nephrology
    |August 10, 2019
    PubMed

    Insights

    Chronic kidney disease (CKD) is a common complication in HIV patients. Early detection and access to antiretroviral therapy (ART) improve kidney function, survival rates for dialysis, and transplant outcomes.

    Area of Science:

    • Nephrology
    • Infectious Diseases
    • HIV Medicine

    Background:

    • Chronic kidney disease (CKD) is a significant complication of HIV infection.
    • HIV-associated nephropathy (HIVAN) and HIV-immune complex disease are key renal manifestations.
    • The advent of antiretroviral therapy (ART) has altered the landscape of HIVAN, increasing focal segmental glomerulosclerosis prevalence.

    Purpose of the Study:

    • To review the impact of HIV infection on kidney health.
    • To discuss the role of antiretroviral therapy (ART) in managing HIV-related kidney disease.
    • To highlight the importance of early detection and management strategies for CKD in HIV-positive individuals.

    Main Methods:

    • Literature review of studies on HIV and kidney disease.
    • Analysis of the effects of ART on renal function in HIV patients.
    • Examination of outcomes for HIV-positive patients undergoing dialysis or kidney transplantation.

    Main Results:

    • ART has led to a decline in HIVAN incidence and improved overall kidney function.
    • HIV-positive patients on ART show comparable survival rates on dialysis and successful outcomes with kidney transplantation.
    • Many antiretroviral drugs require dose adjustment in patients with CKD.

    Conclusions:

    • Early screening for kidney disease upon HIV diagnosis and annually is crucial.
    • Access to ART and preventative HIV programs are essential for reducing the burden of CKD in HIV.
    • Kidney transplantation and dialysis are viable options for HIV-positive patients with advanced kidney disease.

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