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Related Experiment Video

Updated: Jan 21, 2026

Spectral Reflectometric Microscopy on Myelinated Axons In Situ

Spectral Reflectometric Microscopy on Myelinated Axons In Situ

Published on: July 2, 2018

Turning to myelin turnover.

Tobias J Buscham¹, Maria A Eichel¹, Sophie B Siems¹

¹Department of Neurogenetics, Max Planck Institute of Experimental Medicine, Göttingen, Germany.

Neural Regeneration Research

|August 10, 2019

Summary

This summary is machine-generated.

Adults

Keywords:

central nervous system degradation isotope labeling metabolic labeling myelin plasticity and turnover myelinoid bodies neural plasticity oligodendrocyte tamoxifen

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Area of Science:

Neuroscience
Cell Biology
Myelination Research

Background:

Neural plasticity in the adult central nervous system involves myelin adaptation.
Mature oligodendrocytes continuously replace and degrade myelin sheaths.
This dynamic process influences nerve conduction velocity.

Purpose of the Study:

To review methods for studying adult myelin turnover in vivo.
To highlight historical and current experimental approaches.

Main Methods:

Historical use of radioactive precursors for myelin constituents.
Modern techniques including isotope labeling.
Application of tamoxifen-induced gene targeting in vivo.

Main Results:

Myelin turnover is a slow but constant process in adult animals.
This turnover represents a balance between myelin replenishment and degradation.
The rate of turnover can be influenced by various factors.

Conclusions:

Understanding myelin turnover is crucial for comprehending neural plasticity.
Advanced techniques allow for precise investigation of myelin dynamics.
Further research into myelin turnover can reveal insights into neurological health and disease.