Related Experiment Video

Updated: Jan 21, 2026

Full-root Aortic Valve Replacement by Stentless Aortic Xenografts in Patients with Small Aortic Roots
12:17

Full-root Aortic Valve Replacement by Stentless Aortic Xenografts in Patients with Small Aortic Roots

Published on: May 21, 2017

11.8K

Prognostic role of diastolic dysfunction in patients undergoing transcatheter aortic valve replacement

Polydoros N Kampaktsis1, Manolis Vavuranakis2, Daniel Y Choi1

  • 1Department of Medicine, New York Presbyterian/Weill Cornell Medical College, New York, New York.

Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions
|August 10, 2019
PubMed

Insights

Severe diastolic dysfunction (DD) in transcatheter aortic valve replacement (TAVR) patients increases mortality risk, but this link weakens when considering other factors like mitral annular calcification (MAC). Further research is needed for TAVR outcomes.

Area of Science:

  • Cardiology
  • Cardiac Surgery
  • Interventional Cardiology

Background:

  • Left ventricular diastolic dysfunction (DD) is linked to higher mortality post-surgical aortic valve replacement.
  • Limited data exists on DD's impact on outcomes following transcatheter aortic valve replacement (TAVR).
  • Mitral annular calcification (MAC) complicates DD assessment using tissue Doppler imaging in TAVR patients.

Purpose of the Study:

  • To evaluate the role of baseline diastolic dysfunction (DD) on outcomes after transcatheter aortic valve replacement (TAVR).
  • To investigate the influence of mitral annular calcification (MAC) on the association between DD and TAVR outcomes.

Main Methods:

  • Retrospective analysis of 359 TAVR patients, excluding those with atrial fibrillation, mitral valve prostheses, or severe mitral stenosis.
  • Patients classified as severe or non-severe DD based on elevated left ventricular filling pressures.
  • Outcome measure: all-cause mortality or heart failure hospitalization, analyzed with and without propensity-matched cohorts.

Main Results:

  • Severe DD was initially associated with increased risk of mortality or heart failure hospitalization (HR 2.02).
  • This association was no longer significant in the propensity-matched cohort.
  • The Society of Thoracic Surgeons (STS) score was the sole independent predictor of adverse outcomes (HR 1.1).

Conclusions:

  • Baseline severe DD showed an association with increased mortality or heart failure hospitalization post-TAVR.
  • This association was not independent of other structural parameters and known outcome predictors.
  • The independent prognostic value of DD in TAVR patients, especially with MAC, requires further investigation.
Abstract

Keywords:
diastolic dysfunctiontranscatheter aortic valve replacement

More Related Videos

Transcatheter Pulmonary Valve Replacement from Autologous Pericardium with a Self-Expandable Nitinol Stent in an Adult Sheep Model05:31

Transcatheter Pulmonary Valve Replacement from Autologous Pericardium with a Self-Expandable Nitinol Stent in an Adult Sheep Model

Published on: June 8, 2022

3.4K
Standardized Technique of Aortic Valve Re-implantation for Valve-sparing Aortic Root Replacement14:14

Standardized Technique of Aortic Valve Re-implantation for Valve-sparing Aortic Root Replacement

Published on: December 11, 2017

14.6K

Related Concept Videos

Heart Valves01:16

Heart Valves

The human heart is a complex organ with an intricate system of valves that regulate blood flow. There are two main types of valves: atrioventricular (AV) valves and semilunar valves.
The AV valves prevent the backflow of blood from the ventricles to the atria during ventricular contraction. These valves function with the assistance of the chordae tendineae and papillary muscles. When the ventricles are relaxed, the chordae tendineae are slack, allowing blood to flow from the atria into the...
11.3K
Continuous Renal Replacement Therapy01:30

Continuous Renal Replacement Therapy

Continuous Renal Replacement Therapy, also known as CRRT, is a procedural treatment for acute kidney injury (AKI) that gradually removes uremic toxins and fluids while maintaining acid-base balance and stabilizing electrolytes. It is particularly useful for hemodynamically unstable patients. Unlike intermittent hemodialysis, which is faster, CRRT provides a gentler approach over 24 hours, closely mimicking the function of natural kidneys. However, CRRT is not ideal for patients with...
894
Mitral Valve Prolapse I: Introduction01:27

Mitral Valve Prolapse I: Introduction

IntroductionThe mitral valve, one of the heart's four valves, regulates blood flow. These valves have flaps that open and close to direct blood properly through the heart and body. During each heartbeat, the flaps open for blood to pass through and seal shut to prevent backflow. Specifically, the mitral valve opens to allow blood flow from the heart's upper left chamber to the lower left chamber. It then closes securely as the lower left chamber contracts to pump blood to the body, preventing...
401
The Role of Culture01:23

The Role of Culture

Culture plays a crucial role in shaping self-identity and influencing thought and behavior, a foundational interest within social psychology. The multicultural perspective recognizes that individuals do not exist in a vacuum; instead, their experiences, perceptions, and actions are deeply influenced by the intersecting dimensions of their cultural, ethnic, and social group affiliations.Cultural Influence on Self-Identity and Social PerceptionCultural frameworks inform how individuals define...
361
Role of Septins01:02

Role of Septins

Septins are the recently discovered fourth major protein component of the cytoskeleton, along with microfilaments, microtubules, and intermediate filaments. These proteins can associate with other cytoskeletal filaments and carry out varied roles or can be free-floating in the cytoplasm.
Cellular Functions of Septins
Recent studies have revealed the multifaceted roles of septins in various cellular processes such as cytokinesis, ciliogenesis, and neurogenesis. Septins act as scaffolds and...
2.1K
Aortic Regurgitation I: Introduction01:15

Aortic Regurgitation I: Introduction

IntroductionAortic regurgitation is characterized by the backward flow of blood from the aorta into the left ventricle during diastole and arises from the improper closure of the aortic valve. This condition results in left ventricular volume overload and can stem from both acute and chronic etiologies, each contributing uniquely to the disease's progression and symptomatology.Acute and Chronic CausesAcute aortic regurgitation often results from events that suddenly impair the integrity of the...
512