General immunological reactivity of patient's organism with chronic hepatitis С

Introduction: Nowadays, the number of chronic carriers of hepatitis C virus (HCV) is considered to be from around 150 to 500 million by the most of infectionists and epidemiologists. Being one of the most dangerous diseases of the liver of viral etiology hepatitis C increases annually. The aim: To determine the level of general immunological reactivity of patients with chronic hepatitis C.

Materials and methods: This study does not contradict the principles of the Helsinki Declaration (2013), the European Convention on Human Rights and Biomedicine. A clinical and laboratory examination of 31 patients with chronic hepatitis C was conducted during 2014-2015 on the basis of the infectious department of Chernivtsi Regional Clinical.

Results: The initial condition of clinical and laboratory examination of patients with chronic hepatitis C is normally considered to be a clinical examination of each patient and first of all hemograms where absolute and relative number of major populations of immunocompetent cells, platelets, erythrocytes and erythrocyte sedimentation rates (ESR) were determined.

Conclusions: General immunological reactivity in patients with chronic hepatitis C increased to 30,07% and the factors activation and mechanisms of nonspecific anti-infection protection decreased that create a condition for prolonged persistence of hepatitis C virus and the progression of a chronic infectious process in patients' organism.