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Updated: Jan 21, 2026
09:45
Radiosensitivity of Cancer Stem Cells in Lung Cancer Cell Lines
Published on: August 21, 2019
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Definition of Synchronous Oligometastatic Non-Small Cell Lung Cancer-A Consensus Report
Anne-Marie C Dingemans1, Lizza E L Hendriks2, Thierry Berghmans3
1Department of Pulmonary Diseases, Maastricht University Medical Center+, Maastricht, the Netherlands; Department of Pulmonary Diseases, Erasmus Medical Centre, Rotterdam, The Netherlands; GROW - School for oncology and developmental biology, University Maastricht, The Netherlands.
Summary
A consensus defined synchronous oligometastatic (sOM) non-small cell lung cancer (NSCLC) for radical treatment. This definition aids in standardizing clinical trials for improved patient outcomes.
Area of Science:
- Oncology
- Pulmonology
- Medical Imaging
Background:
- Synchronous oligometastatic (sOM) non-small cell lung cancer (NSCLC) patients benefit from radical treatment.
- A lack of uniform definition for sOM NSCLC hinders consistent clinical trial inclusion.
Purpose of the Study:
- To establish a consensus-based definition and diagnostic criteria for sOM NSCLC.
- To standardize criteria for patient selection in clinical trials.
Main Methods:
- A pan-European multidisciplinary consensus group was formed.
- Consensus questions addressed current controversies, utilizing survey data, case studies, and a systematic review.
- A consensus meeting formulated the definitive statement.
Main Results:
- sOM NSCLC definition is relevant when radical treatment is feasible for all sites with acceptable toxicity.
- Proposed criteria include a maximum of five metastases across three organs (excluding mediastinal lymph nodes).
- Recommended imaging includes PET-CT and brain imaging; MRI for liver, thoracoscopy/biopsy for pleural metastases; pathological confirmation advised for mediastinal staging if treatment-influencing.
Conclusions:
- A consensus statement defining and staging sOM NSCLC has been developed.
- This standardized definition will facilitate consistent patient selection for future clinical trials.
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