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Bilateral Serous Retinal Detachment from Neonatal-Onset Multisystemic Inflammatory Disorder.
Brittney Statler1, Tineke Chan2, Wendy Chen1
1Alpert Medical School of Brown University, Division of Ophthalmology, Providence, Rhode Island.
Rhode Island Medical Journal (2013)
|August 11, 2019
Summary
Neonatal-onset Multisystem Inflammatory Disorder (NOMID) can cause serous retinal detachments in infants. Early recognition of this rare condition is crucial for timely treatment and vision preservation.
Area of Science:
- Ophthalmology
- Rheumatology
- Pediatrics
Background:
- Neonatal-onset Multisystem Inflammatory Disorder (NOMID) is a rare autoinflammatory disease.
- Ocular manifestations are common, including optic disc edema and uveitis.
Observation:
- A case report details an infant with NOMID presenting with optic disc edema.
- Ophthalmologic examination revealed bilateral serous retinal detachments (RD).
- MRI showed ocular choroidal enhancement and ventricular enlargement.
Findings:
- The patient was treated with anakinra, an interleukin-1 receptor antagonist.
- Serous retinal detachments resolved within three months of treatment.
- This case highlights a novel ocular finding in NOMID.
Implications:
- Physicians should consider NOMID in infants with unexplained rash, joint swelling, and optic disc edema.
- Serous retinal detachments may be an underrecognized sign of NOMID.
- Prompt diagnosis and treatment with IL-1 receptor antagonists can lead to resolution of ocular manifestations.
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