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Related Experiment Video

Updated: Jan 21, 2026

Quadruple Immunostaining of the Olfactory Bulb for Visualization of Olfactory Sensory Axon Molecular Identity Codes

Quadruple Immunostaining of the Olfactory Bulb for Visualization of Olfactory Sensory Axon Molecular Identity Codes

Published on: June 5, 2017

Inter-axonal recognition organizes Drosophila olfactory map formation.

Gaurav Goyal¹, Ariane Zierau², Marc Lattemann²

¹Department for Neurobiology, University of Vienna, Althanstrasse 14, 1090, Vienna, Austria. gaurav.goyal@univie.ac.at.

Scientific Reports

|August 11, 2019

Summary

In Drosophila, the Dscam receptor guides olfactory sensory neuron axons to form odor maps. Dscam diversity is crucial for this self-organizing process, revealing convergent evolution in olfactory system development.

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Area of Science:

Neuroscience
Developmental Biology
Olfactory System Research

Background:

Olfactory systems in animals share organizational similarities.
In mice and Drosophila, olfactory sensory neurons express single odorant receptors (ORs).
Axon sorting into synaptic glomeruli is OR class-specific in mice.

Purpose of the Study:

To investigate the mechanism of odotopic map formation in Drosophila.
To determine the role of Dscam in olfactory sensory neuron connectivity and axon sorting.
To explore the evolutionary convergence of olfactory map formation.

Main Methods:

Studied sensory neurons mutant for the Ig-domain receptor Dscam.
Utilized mosaic analysis to examine Dscam function.
Investigated single Dscam isoform expression in projecting axons.

Main Results:

Dscam directs OR class-specific axon sorting into glomeruli in Drosophila, independent of target cells.
Dscam prevents premature recognition among sensory axons of the same OR class.
Dscam diversity is essential for spatially restricted glomerular convergence.

Conclusions:

Dscam-mediated self-patterning of sensory neurons is a central mechanism for odotopic map formation in Drosophila.
This process highlights convergent evolution in olfactory map development across species.
Temporal-spatial regulation of Dscam activity controls class-specific axon sorting.