Related Experiment Video
Updated: Jan 21, 2026

FISH for Pre-implantation Genetic Diagnosis
Published on: February 23, 2011
[Prenatal diagnosis of partial trisomy 3q in a fetus]
Ning Su1, Guiyu Lou, Hongdan Wang
1Medical Genetics Institute of Henan Province, People' s Hospital of Zhengzhou University, Henan Provincial People' s Hospital, Zhengzhou, Henan 450003, China. ychslshx@126.com.
Objective:
To carry out prenatal diagnosis for a fetus with ultrasonographic abnormality.
Methods:
Chromosomal karyotyping and array comparative genomic hybridization (array-CGH) analysis were applied for the diagnosis. Peripheral blood samples were also taken from the parents for chromosome karyotyping analysis.
Results:
The fetal karyotype showed additional material of unknown-origin attached to Yq. Array CGH analysis confirmed that the material was derived from 3q22.1q29. The father was found to carry a balanced translocation 46, X, t(Y;3)(q12;q23) (which was diagnosed as 46,XY,Y≥18 elsewhere), whilst the mother was found to be normal.
Conclusion:
3q partial trisomy may present as malformation of multiple systems. Combination of chromosome karyotyping and array-CGH can provide reliable diagnosis for fetuses with abnormalities by ultrasonography.
More Related Videos
Related Concept Videos
Development of the Sexual Organs in the Embryo and Fetus
Near the gonadal ridges, two duct systems are present: the mesonephric ducts (Wolffian ducts) and paramesonephric ducts (Müllerian ducts). These ducts form the basis for the...
Nursing Diagnosis
The nursing diagnosis focuses on evidence-based...
Mixtures of Gases: Dalton's Law of Partial Pressures and Mole Fractions
Documentation of Nursing Diagnosis
In some settings, data-driven computerized decision support systems are in place, allowing for more accurate nursing diagnoses. The database within one of these systems includes diagnostic labels defining characteristics, activities, and indicators for nursing. A nurse enters...
Dalton's Law of Partial Pressure
Formulating and Validating Nursing Diagnosis I
There are thirteen domains...

