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Updated: Jan 21, 2026
Visualization and Quantification of Mesenchymal Cell Adipogenic Differentiation Potential with a Lineage Specific Marker
Published on: March 31, 2018
[Pathogenic genes and adipogenic differentiation transcription factor PPARγ associated with congenital lipodystrophic
Xuan Zhang1, Yuanyuan Qin, Faquan Lin
1Department of Laboratory Medicine, the First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, China. fqlin@163.com.
Abstract:
Congenital lipodystrophic diabetes (CLD) is a rare genetic disease characterized by generalized or topical subcutaneous fat loss combined with various metabolic disorders such as insulin resistance, dyslipidemia, and impaired glucose tolerance. Recent studies have discovered genes underlying the disease. Mutations of such genes are associated with adipogenic anomaly, especially regulational function of peroxisome proliferators-activated receptor γ (γPPAR) for lipid. This paper has provided a review for the main clinical symptoms, classification, pathogenic genes, molecular mechanism and the relationship between PPARγ and fat loss.
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