Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Nitrite inhalants: historical perspective.

G R Newell1, M R Spitz, M B Wilson

  • 1Department of Cancer Prevention and Control, University of Texas, M.D. Anderson Hospital, Houston 77030.

NIDA Research Monograph
|January 1, 1988
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Regional variation in composition and antimicrobial activity of US propolis against Paenibacillus larvae and Ascosphaera apis.

Journal of invertebrate pathology·2014
Same author

Polymorphisms in the N acetyltransferase 1 NAT1 gene and lung cancer risk in a minority population.

Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals·2013
Same author

Sensation-seeking genes and physical activity in youth.

Genes, brain, and behavior·2012
Same author

Evolutionary evidence of the effect of rare variants on disease etiology.

Clinical genetics·2010
Same author

Comparison of discriminatory power and accuracy of three lung cancer risk models.

British journal of cancer·2010
Same author

Expression of methylation-related genes is associated with overall survival in patients with non-small cell lung cancer.

British journal of cancer·2008
Same journal

EVALUATION OF DRUG ABUSE TREATMENT MEDICATIONS: CONCORDANCE BETWEEN CLINICAL AND PRECLINICAL STUDIES.

NIDA research monograph·2006
Same journal

Problems of drug dependence 1999: Proceedings of the 61st annual scientific meeting, the College on Problems of Drug Dependence, Inc.

NIDA research monograph·2001
Same journal

Problems of drug dependence 1997: proceedings of the 59th annual scientific meeting.

NIDA research monograph·1998
Same journal

Laboratory Behavioral Studies of Vulnerability to Drug Abuse. Proceedings of a meeting. August 2-3, 1994.

NIDA research monograph·1998
Same journal

Disaggregating the liability for drug abuse.

NIDA research monograph·1998
Same journal

Integrating genetic and behavioral models in the study of substance abuse mechanisms.

NIDA research monograph·1998
See all related articles

Inhaling nitrites, toxic substances, may contribute to AIDS-related Kaposi

Area of Science:

  • Toxicology
  • Epidemiology
  • Oncology

Background:

  • Volatile nitrites, including amyl, butyl, and isobutyl nitrites, possess toxic properties.
  • Metabolism of N-nitroso compounds yields mutagenic, teratogenic, and carcinogenic products.
  • N-nitroso compounds are potent carcinogens in numerous animal species.
  • Volatile nitrites have demonstrated detrimental effects on human lymphocytes in vitro and in vivo.

Purpose of the Study:

  • To investigate the potential role of nitrite inhalation in the development of acquired immunodeficiency syndrome (AIDS)-related Kaposi's sarcoma (KS).
  • To explore the association between recreational nitrite use and the outbreak of the AIDS epidemic.

Main Methods:

  • Review of pharmacological properties of volatile nitrites.

Related Experiment Videos

  • Analysis of N-nitroso compound metabolism and carcinogenicity data.
  • Examination of epidemiological data linking nitrite use and KS incidence in homosexual males.
  • Correlation of nitrite exposure timelines with AIDS epidemic onset.

    • Main Results:

    • Nitrite inhalation presents significant toxicological and carcinogenic risks.
    • A temporal association exists between the rise in recreational nitrite use and the AIDS epidemic.
    • Extensive nitrite use is prevalent among male homosexuals, particularly those diagnosed with KS.
    • The age demographic of KS patients aligns with a cohort exposed to nitrites 7-10 years prior.

    Conclusions:

    • Nitrite inhalation is a plausible contributing factor to AIDS-related Kaposi's sarcoma in young homosexual males.
    • Further research into the specific mechanisms and epidemiological links is warranted.