p19INK4d: More than Just a Cyclin-Dependent Kinase Inhibitor

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Updated: Jan 21, 2026

Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an In Vitro Kinase Assay
12:26

Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an In Vitro Kinase Assay

Published on: May 3, 2018

19.3K

Xu Han1, Yijin Kuang1, Huiyong Chen1

  • 1Molecular Biology Research Center and the Center for Medical Genetics, School of Life Sciences, Central South University, Changsha, Hunan, China.

Current Drug Targets
|August 11, 2019
PubMed

Insights

p19INK4d, a cell cycle regulator, impacts apoptosis, DNA repair, and senescence. Understanding its gene expression network and functions is key for developing p19INK4d as a therapeutic drug target for various diseases.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Genetics

Background:

  • Cyclin-dependent kinase inhibitors (CDKIs) are crucial for cell cycle regulation.
  • The CDKI family includes INK4 and CIP/KIP subfamilies.
  • p19INK4d is a member of the INK4 family, implicated in physiological processes and disease pathogenesis.

Purpose of the Study:

  • To review the regulatory network of p19INK4d gene expression.
  • To summarize the diverse biological functions of p19INK4d.
  • To provide a foundation for targeting p19INK4d in disease treatment.

Main Methods:

  • Literature review of transcriptional and posttranscriptional regulation of p19INK4d.
  • Analysis of p19INK4d's roles in cell cycle, apoptosis, DNA repair, and differentiation.
  • Synthesis of information on p19INK4d's involvement in cellular senescence.

Main Results:

  • p19INK4d expression is controlled by multiple regulatory factors at different levels.
  • p19INK4d is involved in cell cycle control, apoptosis, DNA damage repair, hematopoietic cell differentiation, and senescence.
  • Dysregulation of p19INK4d contributes to disease development.

Conclusions:

  • The regulatory network and biological functions of p19INK4d are complex and multifaceted.
  • Further research into p19INK4d presents opportunities for novel therapeutic strategies.
  • p19INK4d holds potential as a drug target for treating various diseases.
Keywords:
CDKICIP/KIPINK4biological functionexpression regulationp19INK4d.

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