Temperature-dependent viscosity dominated transport control through AQP1 water channel

We give a supplementary explanation for previous results about the exclusion of proton as well as hydronium (ion) transport through aquaporins (AQP1) via verified transition state theory by calculating the temperature-dependent viscosity for proton or hydronium (ion) transport through AQP1. We will demonstrate the temperature-dependent viscosity dominated transport control in AQP1 via the selected activation energy as well as the activation volume considering the presumed wavy-roughness along the sub-nano domains. Our numerical results show that once proton or hydronium (ion) transport through AQP1 at room temperature behaves like a molecular fluid with a relatively high viscosity, such as pitch, then proton or hydronium (ion) transport through AQP1 will be blocked (like a solid). Otherwise, proton or hydronium (ion) transport through AQP1 at room temperature manifests like a molecular fluid with a correspondingly lower viscosity, such as water (H₂O), and then exclusion of proton or hydronium (ion) through AQP1 will not occur. We also demonstrate possible size effect in blocking proton or hydronium (ion) transport through AQP1. Our predicted results are new and novel as there are no temperature-dependent viscosity measurements relevant to AQP1 yet.