Nanocarrier-based systems for targeted and site specific therapeutic delivery
Joydeb Majumder1, Oleh Taratula2, Tamara Minko3
1Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, the State University of New Jersey, Piscataway, NJ 08854, USA.
Advanced Drug Delivery Reviews
|August 11, 2019
Summary
Nanoparticle drug delivery enhances treatment efficacy and reduces side effects compared to traditional methods. Targeted nanocarriers and living cells offer advanced therapeutic potential for improved drug and nucleic acid delivery.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Pharmacology
Background:
- Systemic drug delivery (oral, parenteral) shows low efficacy and significant adverse effects.
- Nanoparticle-based drug delivery improves efficacy, pharmacokinetics, and release profiles, while limiting side effects.
- Targeted nanocarriers, especially with local administration, offer further enhancements in efficacy and side effect reduction.
Purpose of the Study:
- To review the advantages and limitations of various nanocarrier systems for drug and nucleic acid delivery.
- To highlight emerging frontiers in nanomedicine, including organic and inorganic nanocarriers and cell-based systems.
Main Methods:
- Literature review of organic and inorganic nanocarriers.
- Analysis of living cell-based drug and nucleic acid delivery systems.
- Discussion of nanoparticles, supramolecular gels, and therapeutic cells as drug carriers.
Main Results:
- Nanoparticles enhance drug efficacy and pharmacokinetics.
- Targeted nanocarriers combined with local administration maximize therapeutic benefits.
- Living cells are emerging as novel drug carriers.
Conclusions:
- Nanocarrier-based drug delivery systems represent a significant advancement in medicine.
- Targeted delivery and innovative carriers like supramolecular gels and therapeutic cells are key areas for future development.
Keywords:
Cell-based carriersDrugDrug targetingOrganic and inorganic nanoparticlesSupramolecular gelsiRNA and nucleotide deliveryMore Related Videos
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