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Updated: Jan 21, 2026

Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study
Published on: August 15, 2016
Beta-cyclodextrin-functionalized CdS nanorods as building modules for ultrasensitive photoelectrochemical bioassay of
Jing Fan1, Yang Zang1, Jingjing Jiang1
1School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, Jiangsu, 225002, PR China.
Abstract:
Nowadays, acquired immunodeficiency syndrome has become a formidable danger to human health, and its early diagnosis is urgent need with the increasing quantity of patients around the world. Herein, we first synthesized beta-cyclodextrin-functionalized CdS nanorods (β-CD@CdS NRs) with high stability and desirable photo-electricity activity, and served as easy-to-assemble building modules to design a novel photoelectrochemical biosensor for human immune deficiency virus (HIV) DNA detection by coupling with catalytic hairpin assembly (CHA)-mediated biocatalytic precipitation and the host-guest interaction between adamantine (ADA) and β-CD. In the presence of HIV DNA, CHA process was triggered with the aid of hairpin DNA1 and ADA-labelled hairpin DNA2, and then generated large amounts of G-quadruplex, which could be formed hemin/G-quadruplex DNAzyme to catalyze 4-chloro-1-naphthol to generate insoluble precipitation on photoelectrode surface, followed by the decreased photocurrent response due to the corresponding stereo-hindrance effect. Under optimized conditions, this biosensor exhibited wide linear dynamic range (10 fM - 1 nM) and low detection limit of 1.16 fM, as well as high sensitivity, excellent stability, and satisfactory feasibility in human-serum samples. Moreover, the prepared β-CD@CdS NRs could be applied to the construction of other advanced sensing platform, showing great prospect in clinical diagnostics.
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