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Pediatric Kidney Transplantation in Patients With Urologic Anomalies

Ipek Kaplan Bulut1, Sevgin Taner1, Ahmet Keskinoglu1

  • 1Pediatric Nephrology, Ege University Faculty of Medicine, İzmir, Turkey.

Transplantation Proceedings
|August 12, 2019
PubMed

Insights

Pediatric kidney transplant recipients with end-stage renal disease due to urologic issues show favorable graft survival. This study found no significant difference in outcomes between patients with normal or impaired bladder function undergoing renal transplantation.

Area of Science:

  • Pediatric Nephrology
  • Urology
  • Transplantation Immunology

Background:

  • End-stage renal disease (ESRD) in children often results from structural urologic anomalies.
  • Impaired bladder function is a concern for kidney graft outcomes in pediatric ESRD patients.
  • Understanding graft survival in this population is crucial for optimizing treatment strategies.

Purpose of the Study:

  • To evaluate the single-center experience and long-term outcomes of pediatric renal transplantation for urologic reasons.
  • To compare graft survival rates between pediatric patients with urologic indications (with and without impaired bladder function) and those with non-urologic indications.

Main Methods:

  • Retrospective analysis of 83 pediatric renal transplant recipients (<18 years) between 1998 and 2018.
  • Group A: Urologic reasons, normal bladder function. Group B: Urologic reasons, impaired bladder function. Group C: Non-urologic reasons (control).
  • Graft survival and last-visit creatinine values were compared across groups.

Main Results:

  • No significant difference in creatinine values at the last visit between the groups.
  • One-, 5-, and 10-year graft survival rates were high across all groups: Group A (97%, 89%, 74%), Group B (100% all years), Group C (97%, 94%, 80%).
  • Statistical analysis showed no significant difference in graft survival between the groups (P=.351).

Conclusions:

  • Pediatric patients with ESRD secondary to urologic abnormalities are suitable candidates for kidney transplantation.
  • Favorable graft function and survival can be achieved in these patients.
  • Bladder function status does not appear to significantly impact long-term graft survival in this cohort.
Abstract

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